Impact of radiobiological parameters on tumor control probability in rectal cancer using the Poisson linear quadratic model

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-05-06 DOI:10.1016/j.radphyschem.2025.112902

Duong Thanh Tai, Nguyen Ngoc Anh, Luong Tien Phat, Tran Trung Kien, Nguyen Xuan Hai, Nguyen Huu Tiep, Peter Sandwall, Hiba Omer, Abdelmoneim Sulieman, Nissren Tamam, James C.L. Chow

{"title":"Impact of radiobiological parameters on tumor control probability in rectal cancer using the Poisson linear quadratic model","authors":"Duong Thanh Tai, Nguyen Ngoc Anh, Luong Tien Phat, Tran Trung Kien, Nguyen Xuan Hai, Nguyen Huu Tiep, Peter Sandwall, Hiba Omer, Abdelmoneim Sulieman, Nissren Tamam, James C.L. Chow","doi":"10.1016/j.radphyschem.2025.112902","DOIUrl":null,"url":null,"abstract":"We explore several radiobiological parameters, specifically the tissue-specific linear quadratic α/β, the maximum normalized gradient of dose response γ, and the dose giving a 50 % response probability for the tissue considered D<ce:inf loc=\"post\">50</ce:inf>, looking at how these affect the computed Tumor Control Probabilities (TCPs) within the Poisson Linear Quadratic (LQ) model. A total of 3,584,000 TCP values were derived for 28 rectal cancer patients, utilizing two slightly different treatment plans: the short plan (50 Gy in 25 fractions) and the long plan (50.4 Gy in 28 fractions), along with 64,000 parameter combinations. TCP was calculated using the Poisson LQ model, which combines radiobiological parameters (α/β, γ, and D<ce:inf loc=\"post\">50</ce:inf>) with the voxel-based Equivalent Dose (EQD). Our analysis reveals that D<ce:inf loc=\"post\">50</ce:inf> has the most significant influence, followed by γ, while α/β has minimal impact. Moreover, the influence of γ depends on the specific D<ce:inf loc=\"post\">50</ce:inf> value employed. Furthermore, comparing TCPs obtained for short and long plans, these consistently show the TCP of the short plan to surpass that of the long plan when the same radiobiological parameter values are used. This study suggests that evaluating treatment plan efficacy through TCPs it is appropriate to use consistent parameter values within the Poisson Linear Quadratic model.","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"14 1","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Physics and Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.radphyschem.2025.112902","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

We explore several radiobiological parameters, specifically the tissue-specific linear quadratic α/β, the maximum normalized gradient of dose response γ, and the dose giving a 50 % response probability for the tissue considered D50, looking at how these affect the computed Tumor Control Probabilities (TCPs) within the Poisson Linear Quadratic (LQ) model. A total of 3,584,000 TCP values were derived for 28 rectal cancer patients, utilizing two slightly different treatment plans: the short plan (50 Gy in 25 fractions) and the long plan (50.4 Gy in 28 fractions), along with 64,000 parameter combinations. TCP was calculated using the Poisson LQ model, which combines radiobiological parameters (α/β, γ, and D50) with the voxel-based Equivalent Dose (EQD). Our analysis reveals that D50 has the most significant influence, followed by γ, while α/β has minimal impact. Moreover, the influence of γ depends on the specific D50 value employed. Furthermore, comparing TCPs obtained for short and long plans, these consistently show the TCP of the short plan to surpass that of the long plan when the same radiobiological parameter values are used. This study suggests that evaluating treatment plan efficacy through TCPs it is appropriate to use consistent parameter values within the Poisson Linear Quadratic model.

查看原文本刊更多论文

用泊松线性二次模型研究放射生物学参数对直肠癌肿瘤控制概率的影响

我们探讨了几个放射生物学参数，特别是组织特异性线性二次型α/β，剂量反应的最大归一化梯度γ，以及给予考虑D50的组织50%反应概率的剂量，看看这些如何影响泊松线性二次型（LQ）模型中计算的肿瘤控制概率（tcp）。28例直肠癌患者共获得358.4万个TCP值，采用两种略有不同的治疗方案：短期计划（25组50 Gy）和长期计划（28组50.4 Gy），以及6.4万个参数组合。TCP采用泊松LQ模型计算，该模型结合放射生物学参数（α/β、γ和D50）和基于体素的等效剂量（EQD）。我们的分析表明，D50的影响最显著，其次是γ，而α/β的影响最小。此外，γ的影响取决于所采用的特定D50值。此外，比较短期方案和长期方案得到的TCP，在使用相同的放射生物学参数值时，一致表明短期方案的TCP优于长期方案。本研究提示，通过tcp来评价治疗方案的疗效，宜采用泊松线性二次模型内一致的参数值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.