Effects of Juvenile Idiopathic Inflammatory Myopathies on Growth, Development, and Maturation: A Systematic Review and Meta-Analysis.

The Journal of Rheumatology Pub Date : 2025-05-15 DOI:10.3899/jrheum.2024-0088

Jessica C Guo,Olivia D Garisto,Jessie Cunningham,Y Ingrid Goh,Jill Hamilton,Brian M Feldman

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Abstract

OBJECTIVE The purpose of this review is to assess the effects of JIIM on growth and pubertal development. METHODS A systematic review was conducted by searching EMBASE, MEDLINE, PubMed®, PsycINFO, Cochrane, and Web of Science to identify studies published in English from inception to December 2024. Data were extracted regarding puberty- and development-related outcomes. Meta-analyses were conducted for outcomes measured consistently across studies, using the R package metafor (Version 3.4-0). RESULTS Of 5,838 identified unique records, 24 were included. Inter-rater reliability for abstract and full-text screening was Κ=0.93 and Κ=1.0, respectively. Eighteen articles discussed growth (14/18 demonstrated decreased height or growth failure). Meta-analysis of 7 studies noted the overall prevalence of growth failure is 17.9%, 95% C.I. [10.7-25.0]. Five articles reported delays of secondary sex characteristics or puberty. Five articles discussed age of menarche onset; 4 reported delays and one did not. CONCLUSION JIIM can cause several deleterious effects on development including growth failure. The impact of hormonal changes or delayed puberty has been less well studied. Endocrine abnormalities should be actively screened for and treated. Additional research is needed to assess long-term impacts.

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青少年特发性炎性肌病对生长、发育和成熟的影响：一项系统综述和荟萃分析。

目的探讨JIIM对儿童生长发育和青春期发育的影响。方法通过检索EMBASE、MEDLINE、PubMed®、PsycINFO、Cochrane和Web of Science进行系统评价，确定自成立以来至2024年12月发表的英文研究。数据提取有关青春期和发育相关的结果。使用R包元分析（版本3.4-0）对各研究一致测量的结果进行了荟萃分析。结果在5838条鉴定的独特记录中，有24条被纳入。摘要和全文筛选的评分间信度分别为Κ=0.93和Κ=1.0。18篇文章讨论了生长（14/18证明了身高下降或生长失败）。7项研究的荟萃分析表明，生长衰竭的总体患病率为17.9%,95% C.I.[10.7-25.0]。五篇文章报道了第二性征或青春期的延迟。五篇文章讨论了月经初潮的年龄；4家报告了延误，1家没有。结论jiim可对发育造成包括生长衰竭在内的多种不良影响。荷尔蒙变化或青春期延迟的影响还没有得到很好的研究。内分泌异常应积极筛查和治疗。需要进一步的研究来评估长期影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journal of Rheumatology

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