[Hidradenitis suppurativa, report with dual therapy: small molecules and biological therapy].

Paola Denise Elizalde-Hernández, Andres Jhojairo Solis-González, Fabiola Leonor Méndez-Flores, Lorena Estrada-Aguilar
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引用次数: 0

Abstract

Background: Hidradenitis suppurativa is an immune-mediated disease characterized by abscesses, deep nodules and fistulas that connect them to each other or connect to the surface, creating infectious processes that are difficult to control, healing of fistulas, retractable tracts and painful ulcers of slow evolution that lead the patient to depression and anxiety. Treatment still shows unsatisfactory results for patient health.

Clinic case: A 27-year-old woman with a 5-year history of this pathology in Hurley stage III is presented. Because of failure to treatment with first lines of management. Anti IL-17 biologic was started, with poor response, so JAK inhibitor was added with adequate response at 4 weeks in the modified Hurley scale, VAS of pain and DLQI.

Conclusion: Combined therapy mediated by cytokines and cells of the humoral response of retractile and fistulous lesions in Hurley stages II and III is proposed as an adjuvant in the chronic response of the disease.

[化脓性汗腺炎,报道双重治疗:小分子和生物治疗]。
背景:化脓性汗腺炎是一种免疫介导的疾病,其特征是脓肿、深部结节和瘘管相互连接或连接到表面,产生难以控制的感染过程,瘘管愈合、束缩回和演变缓慢的疼痛溃疡,导致患者抑郁和焦虑。治疗对病人健康的影响仍不理想。临床病例:一个27岁的妇女与5年的历史,这种病理在赫尔利期III提出。由于治疗失败,与第一线的管理。开始抗IL-17生物制剂治疗,疗效较差,故在改良Hurley评分、疼痛VAS评分和DLQI评分4周时加入JAK抑制剂治疗,疗效较好。结论:在Hurley II期和III期中,细胞因子和体液反应细胞介导的联合治疗可作为疾病慢性反应的辅助治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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