Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

IF 5.9 2区 医学 Q1 NUTRITION & DIETETICS
Edward R Payne, Magaly Aceves-Martins, Joy Dubost, Arno Greyling, Baukje de Roos
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引用次数: 0

Abstract

Context: The bioactive compounds found in tea from Camellia sinensis, namely theanine, caffeine, and polyphenols, can potentially improve short-term and long-term health outcomes.

Objective: The aim of this study was to assess the effects of tea, theanine alone, or theanine plus caffeine on cognition, mood, and sleep outcomes, using data from randomized controlled trials (RCTs) in healthy participants.

Data sources: The Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Embase, and Ovid Medline were searched up to and including August 2023.

Data extraction: Data relevant to the participants, interventions, comparisons, outcomes (ie, cognition, mood, and sleep), and study design were extracted.

Data analysis: Fifty RCTs were included in the review, of which 15 were eligible for at least 1 meta-analysis, most commonly performed by use of standardized mean differences (SMD), in random effects models. After intake of theanine plus caffeine, and of placebo, small-to-moderate differences were found between these interventions in the first hour (h1) and second hour (h2), that favoured theanine plus caffeine, with regard to cognition and mood outcomes such as choice reaction time (h1: SMD, -0.48; 95% CI, -1.01, 0.05), digit vigilance task accuracy (h2: SMD, 0.20; 95% CI, 0.02, 0.38), attention switching task accuracy (h2: SMD, 0.33; 95% CI, 0.13, 0.54), and overall mood (h2: SMD, 0.26; 95% CI,-0.10, 0.63). There was a small-to-moderate difference between the effects of theanine and placebo that favored theanine on choice reaction time (h1: SMD, -0.35; 95% CI,-0.61, -0.10). The CIs frequently highlighted the uncertainty surrounding the direction and magnitude of these differences.

Conclusions: This meta-analysis provides evidence that theanine plus caffeine, and theanine alone, could be beneficial for cognitive and mood outcomes. More research using tea beverages or tea-equivalent bioactive doses and research in free-living participants is needed.

Prospero registration no: CRD42022351601.

茶(Camellia sinensis)或其生物活性化合物l-茶氨酸或l-茶氨酸加咖啡因对健康参与者认知、睡眠和情绪的影响:随机对照试验的系统回顾和荟萃分析
背景:在茶树中发现的生物活性化合物,即茶氨酸、咖啡因和多酚,可以潜在地改善短期和长期的健康结果。目的:本研究的目的是评估茶、茶氨酸单独或茶氨酸加咖啡因对认知、情绪和睡眠结果的影响,使用来自健康参与者的随机对照试验(rct)的数据。数据来源:检索Cochrane系统评价数据库、Cochrane中央对照试验注册库、Embase和Ovid Medline,检索截止至2023年8月。数据提取:提取与受试者、干预措施、比较、结果(即认知、情绪和睡眠)和研究设计相关的数据。资料分析:本综述纳入50项随机对照试验,其中15项符合至少1项荟萃分析的条件,最常用的是在随机效应模型中使用标准化平均差异(SMD)。在摄入茶氨酸加咖啡因和安慰剂后,在第一个小时(h1)和第二个小时(h2),在认知和情绪结果(如选择反应时间)方面,发现茶氨酸加咖啡因的干预措施之间存在小到中等的差异(h1: SMD, -0.48;95% CI, -1.01, 0.05),数字警觉性任务准确性(h2: SMD, 0.20;95% CI, 0.02, 0.38),注意切换任务准确性(h2: SMD, 0.33;95% CI, 0.13, 0.54)和整体情绪(h2: SMD, 0.26;95% ci,-0.10, 0.63)。茶氨酸和安慰剂对选择反应时间的影响有小到中等的差异(h1: SMD, -0.35;95% ci,-0.61, -0.10)。ci经常强调围绕这些差异的方向和大小的不确定性。结论:这项荟萃分析提供了证据,证明茶氨酸加咖啡因,以及单独茶氨酸,可能对认知和情绪结果有益。需要对茶饮料或与茶相当的生物活性剂量进行更多的研究,并对自由生活的参与者进行研究。普洛斯彼罗注册号:CRD42022351601。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition reviews
Nutrition reviews 医学-营养学
CiteScore
12.20
自引率
1.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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