The Relationship Between Urinary Incontinence, Mortality, and Frailty: Insights From a Large Cohort Study.

IF 1.8 3区医学 Q3 UROLOGY & NEPHROLOGY

Neurourology and Urodynamics Pub Date : 2025-05-02 DOI:10.1002/nau.70064

Niharika Malviya, Tracy Cheung, Joseph Kim, Kelli Aibel, Chihiro Okada, Nitya Abraham

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引用次数: 0

Abstract

Objective: This study aims to explore the relationship between urinary incontinence (UI) and mortality in women, with a focus on the potential role of frailty and variations across UI subtypes.

Methods: We analyzed 8967 women aged 40 and above who were part of the National Health and Nutrition Examination Survey (NHANES). Kaplan-Meier survival curves and Cox regression analyses were performed to assess the relationship between urge UI (UUI), stress UI (SUI), other UI (OUI) and all-cause mortality. These models were adjusted for demographic variables and frailty scores.

Results: Approximately 45.8% of participants reported UI in the past year. Initial analysis showed a significant association between UI and increased mortality risk (hazard ratio [HR] = 1.478, 95% confidence interval [CI] 1.317-1.657, p < 0.001), persisting after controlling for frailty (HR = 1.151, 95% CI 1.022-1.297, p = 0.021). However, after adjusting for frailty and demographic factors, this association became non-significant.

Conclusion: Women with UI exhibited a significantly increased risk of all-cause mortality, but this association did not hold after accounting for both key demographics and frailty.

查看原文本刊更多论文

尿失禁、死亡率和虚弱之间的关系：来自大型队列研究的见解。

目的：本研究旨在探讨女性尿失禁（UI）与死亡率之间的关系，重点关注虚弱和UI亚型差异的潜在作用。方法：对参加全国健康与营养调查（NHANES）的8967名40岁及以上妇女进行分析。采用Kaplan-Meier生存曲线和Cox回归分析评估急迫性UI （UUI）、应激性UI （SUI）、其他UI （OUI）与全因死亡率之间的关系。这些模型根据人口统计变量和虚弱评分进行了调整。结果：大约45.8%的参与者在过去一年中报告了尿失禁。初步分析显示，尿失尿与死亡风险增加之间存在显著关联（危险比[HR] = 1.478, 95%可信区间[CI] 1.317-1.657, p）。结论：尿失尿女性的全因死亡风险显著增加，但在考虑了关键人口统计学和虚弱因素后，这种关联并不成立。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurourology and Urodynamics 医学-泌尿学与肾脏学

CiteScore

4.30

自引率

10.00%

发文量

231

审稿时长

4-8 weeks

期刊介绍： Neurourology and Urodynamics welcomes original scientific contributions from all parts of the world on topics related to urinary tract function, urinary and fecal continence and pelvic floor function.