Evaluation of the Toxicity Profile and Central Nervous System Activities of Glue (Adhesive) Inhalation in Wistar Rats.

IF 3.4 Q2 TOXICOLOGY

Journal of Toxicology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.1155/jt/5535209

Abdulgafar Olayiwola Jimoh, Shuaibu Abdullahi Hudu, Onyinye Emmanuella Ibeabuchi, Bilyaminu Abubakar, Millicent Ladi Umaru, Zuwaira Sani, Edith Ginika Otalike, Umar Mohammed, Muhammad Sanusi Haruna, Kehinde Ahmad Adeshina

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Abstract

Background: Glue inhalation is a common unconventional substance of abuse, and it contains neurotoxic and volatile solvents. We examined the toxicity profile and central nervous system (CNS) activities of glue inhalation in Wistar rats. Methods: Acute toxicity was investigated, and the subacute toxicity was studied using 24 male Wistar rats at graded concentrations of air, 2, 4 and 8 mL glue (n = 6/group) for 28 days. Blood samples were collected for biochemical and haematological evaluations, and vital organs (lung, liver, kidney, heart, brain and eye) were used for histological analysis. Behavioural studies were carried out using an elevated plus maze, hole board test, open-field test, tail suspension test and forced swim test. Dependence and abstinence effects were also evaluated. Results: The lethal dose (LD₅₀) of the inhalational glue was 14.14 mL. Glue significantly increased liver function parameters such as TB, DB, ALP, ALT, TP and electrolyte levels (K⁺ and HCO₃) but reduced cholesterol levels in exposed rats. Glue inhalation had significant anxiolytic and depressant effects on the rats at concentrations of 4 and 8 mL. Histological analysis revealed liver and lung tissue abnormalities and subconjunctival inflammation in eye tissue at 8 mL. Conclusion: The study therefore suggests that glue inhalation has anxiolytic and depressant effects in Wistar rats.

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吸胶对Wistar大鼠毒性及中枢神经系统活性的评价。

背景：吸胶剂是一种常见的非常规滥用物质，它含有神经毒性和挥发性溶剂。我们观察了吸入胶水对Wistar大鼠的毒性和中枢神经系统（CNS）活性。方法：以24只雄性Wistar大鼠为实验对象，分别以空气、2、4、8 mL胶浓度（n = 6/组）给药28 d，观察急性毒性和亚急性毒性。采集血样进行生化和血液学评估，重要器官（肺、肝、肾、心、脑和眼）进行组织学分析。行为学研究采用高架迷宫、孔板试验、露天试验、悬尾试验和强迫游泳试验。依赖性和戒断效果也进行了评价。结果：吸入胶致死剂量（LD50）为14.14 mL。胶显著增加了暴露大鼠的肝功能参数，如TB、DB、ALP、ALT、TP和电解质水平（K+和HCO3），但降低了胆固醇水平。大鼠吸胶4、8 mL均有明显的抗焦虑和抑制作用。组织学分析显示8 mL时肝、肺组织异常，眼组织结膜下炎症。结论：胶水吸入对Wistar大鼠具有抗焦虑和抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Toxicology TOXICOLOGY-

CiteScore

5.50

自引率

3.40%

发文量

审稿时长

10 weeks

期刊介绍： Journal of Toxicology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of toxicological sciences. The journal will consider articles looking at the structure, function, and mechanism of agents that are toxic to humans and/or animals, as well as toxicological medicine, risk assessment, safety evaluation, and environmental health.