Longitudinal changes and patterns in cardiometabolic index and the natural course of prediabetes in the China health and retirement longitudinal study.
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引用次数: 0
Abstract
Background: Prediabetes is one of the most common metabolic disorders in the aging process. This study aims to investigate the longitudinal changes in the Cardiometabolic Index (CMI) and their relationship with the natural course of prediabetes in middle-aged and elderly populations.
Methods: This study used longitudinal data from the China Health and Retirement Longitudinal Study. The natural course of prediabetes was used to describe the trend in glycemic development during follow-up, defined as progression to diabetes or regression to normoglycaemia. Longitudinal changes in CMI were categorized into CMI transition patterns (consistently-low, low-to-high, high-to-low, and consistently-high) and cumulative CMI (CumCMI) exposure. CumCMI was calculated as the ratio of the mean CMI values measured during the longitudinal surveys to the total duration of exposure.
Results: According to the inclusion and exclusion criteria, a total of 2,544 prediabetic participants from the China Health and Retirement Longitudinal Study cohort were included in the study. During a median follow-up of 3 years, the rates of progression and regression of prediabetes were as follows in the consistently-low, low-to-high, high-to-low, and consistently-high CMI pattern groups: 9.94%, 16.55%, 11.72%, 20.32% for progression; and 24.97%, 22.37%, 23.81%, 20.42% for regression, respectively. Regarding prediabetes progression, our results found that a high baseline CMI level and high CumCMI exposure during follow-up significantly increased the risk of developing diabetes in prediabetic patients. Furthermore, during follow-up, compared to the low-to-high CMI pattern group, the consistently-low CMI pattern was protective for prediabetic patients. Concerning prediabetes regression, we only observed a negative correlation between baseline CMI and follow-up CumCMI exposure with outcomes in the elderly (age ≥ 60 years). Specifically, high baseline CMI levels and high follow-up CumCMI exposure significantly hindered prediabetes regression in the elderly.
Conclusion: In this prospective cohort study of middle-aged and elderly populations, we found that longitudinal changes in CMI were associated with the progression and regression of prediabetes. High CumCMI exposure during follow-up significantly increased the risk of diabetes events and hindered the recovery of normoglycaemia in the elderly. Moreover, maintaining a consistently-low CMI pattern during follow-up reduced the risk of diabetes in prediabetic patients.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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