Clinic-radiological classification of herpesviral encephalitis in humans (systematic review).

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI:10.1007/s13365-025-01250-1
Dmytro Maltsev
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引用次数: 0

Abstract

The development of a comprehensive classification for herpesvirus encephalitis remains an urgent task. Distinct clinic-radiological forms of herpesvirus cerebral lesions have been characterized, including findings from histopathological studies. Differences among these forms have been demonstrated concerning key clinical and paraclinical parameters. The presented classification identifies several distinct forms of herpesvirus encephalitis: temporal, brainstem, limbic, diencephalic encephalitis, rhombencephalitis, leukoencephalitis, ventriculoencephalitis, diffuse glial micronodular encephalitis, subcortical and cortical encephalitis, cerebellitis, neonatal encephalitis. Additionally, the concepts of combined, coexisting and multimodal lesions are introduced to describe complex forms of herpesvirus neuroinfections. The use of the term "specific spectrum of herpesvirus cerebral lesions" is supported. Both the phenomena of specificity and universality are considered. Fundamental differences between the forms of herpesvirus encephalitis are highlighted with respect to their prevalence within the population, etiological factors, clinical manifestations, typical complications, recovery completeness, mortality rates, immune status. The distinctive diagnostic and therapeutic approaches required for each form of herpesvirus encephalitis are emphasized. The integration of this classification into clinical practice has the potential to optimize medical care for patients with herpesvirus encephalitis, enabling not only etiologically-oriented but also form-specific approaches to treatment.

人类疱疹病毒性脑炎的临床-放射学分类(系统综述)。
发展疱疹病毒性脑炎的综合分类仍然是一项紧迫的任务。不同的临床-放射形式的疱疹病毒脑损伤的特点,包括从组织病理学研究结果。这些形式之间的差异已经证明了关键的临床和临床参数。所提出的分类确定了几种不同形式的疱疹病毒脑炎:颞叶、脑干、边缘、间脑脑炎、脑形脑炎、脑白质脑炎、脑室脑炎、弥漫性胶质小结节脑炎、皮质下和皮质脑炎、小脑炎、新生儿脑炎。此外,联合、共存和多模态病变的概念被引入来描述复杂形式的疱疹病毒神经感染。支持使用术语“疱疹病毒脑损伤特异性谱”。同时考虑了特殊性现象和普遍性现象。强调了疱疹病毒脑炎在人群中的流行程度、病因、临床表现、典型并发症、恢复完整性、死亡率和免疫状况等方面的根本差异。强调每种形式的疱疹病毒脑炎需要独特的诊断和治疗方法。将这种分类整合到临床实践中,有可能优化疱疹病毒脑炎患者的医疗护理,不仅能够以病因为导向,而且还能够采用特定形式的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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