Association between polychlorinated biphenyls and hypertension risk: a systematic review and meta-analysis.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1529431

Seyedeh Fatemeh Hamzavi, Iman Elahi Vahed, Ali Samadi Shams, Fateme Nozari, Baroukh Gamzeh Latava, Saman Mardukhi, Behnoosh Sabaghi, Zakieh Sadat Hosseini, Zohre Masoumi Shahr-E Babak, Sahar Ahrari, Ali Keshavarzian, Mohammad Rahmanian

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引用次数: 0

Abstract

Background and aim: Hypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation. This review and meta-analysis aimed to investigate the association between PCB exposure and hypertension.

Methods: Adhering to the PRISMA 2020 guidelines, data sources such as PubMed, Scopus, Web of Science, and Google Scholar were systematically searched up to July 2024 to find observational studies on the link between PCBs and hypertension risk. Studies were reviewed and chosen according to established inclusion and exclusion criteria, focusing on observational studies examining PCB exposure and hypertension risk. Independent reviewers conducted data extraction, and the quality of studies was evaluated using the JBI critical appraisal tool. A meta-analysis with a random-effects model was conducted to determine combined odds ratios (ORs) for hypertension linked to total PCB exposure and specific PCB types.

Results: Of the 494 records identified, 21 studies met the inclusion criteria, comprising 5 cohort studies, 15 cross-sectional studies, and one case-control study, totaling 51,514 participants. Exposure to total PCBs correlated with an elevated risk of hypertension (OR = 1.78, 95% CI: 1.30-2.44). Dioxin-like PCBs were also associated with a heightened risk (OR = 1.54, 95% CI: 1.24-1.90), while non-dioxin-like PCBs were not significantly linked (OR = 1.16, 95% CI: 0.81-1.66). Among individual congeners, PCB-74, PCB-118, PCB-105, and PCB-153 were significantly related to higher hypertension risk.

Conclusion: These findings indicate a positive correlation between PCB exposure and hypertension, particularly with dioxin-like PCBs and certain PCB congeners. Additional research is necessary to clarify the mechanisms involved and to promote measures for reducing PCB exposure, particularly in high-risk populations.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223, PROSPERO (CRD42024595223).

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多氯联苯与高血压风险的关系：一项系统综述和荟萃分析。

背景与目的：高血压（HTN）是一项广泛的全球健康挑战，其发病率的上升归因于个体和环境风险因素。持久性有机污染物（POPs），特别是多氯联苯（PCBs），通过在脂肪组织中积累，导致氧化应激和血管炎症，从而增加心血管风险。本综述和荟萃分析旨在调查多氯联苯暴露与高血压之间的关系。方法：根据PRISMA 2020指南，系统检索截至2024年7月PubMed、Scopus、Web of Science、谷歌Scholar等数据来源，查找多氯联苯与高血压风险关系的观察性研究。根据既定的纳入和排除标准对研究进行了审查和选择，重点是检查多氯联苯暴露和高血压风险的观察性研究。独立审稿人进行数据提取，并使用JBI关键评估工具对研究质量进行评估。采用随机效应模型进行荟萃分析，以确定与总PCB暴露和特定PCB类型相关的高血压的综合优势比（ORs）。结果：在纳入的494份文献中，21项研究符合纳入标准，包括5项队列研究、15项横断面研究和1项病例对照研究，共51,514名受试者。暴露于总多氯联苯与高血压风险升高相关（OR = 1.78, 95% CI: 1.30-2.44）。二恶英样多氯联苯也与较高的风险相关（OR = 1.54, 95% CI: 1.24-1.90），而非二恶英样多氯联苯没有显著关联（OR = 1.16, 95% CI: 0.81-1.66）。在个体同系物中，PCB-74、PCB-118、PCB-105和PCB-153与高血压风险显著相关。结论：这些发现表明多氯联苯暴露与高血压呈正相关，特别是与二恶英样多氯联苯和某些多氯联苯同系物有关。需要进一步的研究来澄清所涉及的机制，并促进减少多氯联苯接触的措施，特别是在高危人群中。系统评价注册：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223, PROSPERO （CRD42024595223）。

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.