A mini review on study of forensically important poisoning cases involving bromadiolone.

IF 1.5 4区医学 Q2 MEDICINE, LEGAL

Forensic Science, Medicine and Pathology Pub Date : 2025-04-23 DOI:10.1007/s12024-025-00991-z

Harishchandra Jirimali, Saiprasad Santre, Shubhangi Deonikar, Bhausaheb More

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引用次数: 0

Abstract

Purpose: This aims to study poisoning cases involving bromadiolone, its detection from biological samples, and treatment for the survival of the victim.

Methods: A literature survey on bromadiolone poisoning using Scopus, PubMed, and World Wide Web using relevant keywords, e.g. Bromadiolone poisoning, bromadiolone toxicology, poisoning treatment, bromadiolone detection, detection methods. The analytical methods like thin layer chromatography, high performance liquid chromatography, gas chromatography, CT scans (computed tomography scan) Magnetic Resonance Imaging (MRI) and combined mass spectroscopic methods were used for the detection of bromadiolone.

Results: Bromadiolone poisoning in different organisms like cats, rats, birds, foxes, and human beings was studied. On the basis of the concentration of bromadiolone and its half-life period, symptoms like internal hemorrhage were observed; in some cases, lesions on the brain were seen. Vitamin K (Vit. K), is the effective treatment for the curing of bromadiolone, was identified.

Conclusions: This review suggests that in the case of bromadiolone poisoning, it is very important to find out the poisoned compound and not to rely only on symptomatic treatment. It is found that Vit. K is the major curative treatment for the survival of bromadiolone poisoning victims.

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涉及溴代洛酮的重要法医中毒案件研究综述。

目的：研究涉及溴代洛酮的中毒病例，从生物样本中检测溴代洛酮，并对受害者的生存进行治疗。方法：采用Scopus、PubMed、World Wide Web等相关关键词，如溴代洛酮中毒、溴代洛酮毒理学、中毒治疗、溴代洛酮检测、检测方法等，对溴代洛酮中毒进行文献调查。采用薄层色谱法、高效液相色谱法、气相色谱法、CT扫描（计算机断层扫描）、磁共振成像（MRI）和联合质谱法等分析方法检测溴代洛酮。结果：对猫、鼠、鸟、狐、人等不同生物的溴代隆中毒进行了研究。根据溴代洛酮浓度及半衰期，观察内出血等症状；在一些病例中，可以看到脑部的病变。维生素K（维生素）K)，是溴代洛酮固化的有效治疗方法。结论：本综述提示，在溴代洛酮中毒病例中，重要的是查明中毒化合物，不能仅仅依靠对症治疗。研究发现，Vit。K是溴代洛酮中毒患者生存的主要治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Forensic Science, Medicine and Pathology MEDICINE, LEGAL-PATHOLOGY

CiteScore

3.90

自引率

5.60%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Forensic Science, Medicine and Pathology encompasses all aspects of modern day forensics, equally applying to children or adults, either living or the deceased. This includes forensic science, medicine, nursing, and pathology, as well as toxicology, human identification, mass disasters/mass war graves, profiling, imaging, policing, wound assessment, sexual assault, anthropology, archeology, forensic search, entomology, botany, biology, veterinary pathology, and DNA. Forensic Science, Medicine, and Pathology presents a balance of forensic research and reviews from around the world to reflect modern advances through peer-reviewed papers, short communications, meeting proceedings and case reports.