Changes of peripheral blood lymphocytes, neutrophils, CEA, TAP and ferritin in colorectal adenoma and colorectal cancer and the diagnostic performance of these makers in evaluating colorectal cancer

IF 1.1 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Arab Journal of Gastroenterology Pub Date : 2025-05-08 DOI:10.1016/j.ajg.2025.03.002

Jialai Zheng , Yongtao Tu , Haiyong Jin , Haiyan Sun , Guanqiao Shen , Haijiang Tong

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引用次数: 0

Abstract

Background and study aims

Colorectal cancer (CRC) has been recognized as a multifactorial disease arising from precursor lesions and characterized by chronic inflammation. Therefore, the inflammatory response is one of the critical indicators for the diagnosis of CRC. Timely and effective screening is an effective strategy to reduce the incidence and mortality of CRC. The primary aim of this study was to analyze the differences in white blood cell count (WBC) in patients with colorectal adenoma (CRA) and CRC. The second aim was to estimate the diagnostic performance of using a panel of serum tumor markers and WBC for CRC screen.

Patients and methods

We retrospectively reviewed a database of patients who were diagnosed with CRA and CRC. Serum tumor markers and blood routine examination data were completed before receiving any anticancer therapy.

Results

A total of 538 participants were enrolled, including 169 health participants, 195 patients with CRA and 174 patients with CRC. Lymphocyte counts were lower in CRC than CRA and healthy participants. Neutrophil counts were higher in CRC and CRA than healthy participants. The CEA levels were higher in CRA and CRC than healthy participants, and higher in CRC than CRA. The areas of tumor TAP were larger in CRC than CRA and healthy participants. The ferritin levels were lower in CRC than CRA and healthy participants. The 8-marker panel yielded an AUC of 0.854 higher than single marker. There is no difference in the diagnostic performance of TAP, CEA, ferritin and NLR.

Conclusions

There are a lot of high sensitivity and specificity methods for CRC screening. However, most screening programs suffer from poor participation rates. Herein, our 8-marker panel is cost-effective and high-performance screen system for the detection of CRC and is crucial for enhancing the participation rates in current screening programs.

查看原文本刊更多论文

外周血淋巴细胞、中性粒细胞、CEA、TAP和铁蛋白在结直肠腺瘤和结直肠癌中的变化及其对结直肠癌的诊断价值

背景与研究目的：结直肠癌（Colorectal cancer， CRC）是一种由前体病变引起的多因素疾病，以慢性炎症为特征。因此，炎症反应是诊断结直肠癌的重要指标之一。及时有效的筛查是降低结直肠癌发病率和死亡率的有效策略。本研究的主要目的是分析结直肠腺瘤（CRA）和结直肠癌患者白细胞计数（WBC）的差异。第二个目的是评估使用一组血清肿瘤标志物和白细胞筛查结直肠癌的诊断性能。患者和方法：我们回顾性地回顾了诊断为CRA和CRC的患者数据库。在接受任何抗癌治疗前完成血清肿瘤标志物和血常规检查资料。结果：共纳入538名参与者，包括169名健康参与者，195名CRA患者和174名CRC患者。CRC患者的淋巴细胞计数低于CRA和健康参与者。CRC和CRA患者的中性粒细胞计数高于健康参与者。CRA组和CRC组CEA水平均高于健康组，CRC组CEA水平高于CRA组。CRC患者的肿瘤TAP面积大于CRA和健康参与者。CRC组的铁蛋白水平低于CRA组和健康组。8个标记组的AUC比单个标记高0.854。TAP、CEA、铁蛋白和NLR的诊断效果无显著差异。结论：目前有很多高灵敏度、高特异性的CRC筛查方法。然而，大多数筛查项目的参与率都很低。因此，我们的8个标记面板是一种成本效益高、高性能的CRC检测筛查系统，对于提高当前筛查计划的参与率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arab Journal of Gastroenterology Medicine-Gastroenterology

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.