Evaluation of dose distributions in the overlapping regions of the modulated volumetric arcs used in total body irradiation in pediatric patients.

IF 1.2 Q4 ONCOLOGY

Reports of Practical Oncology and Radiotherapy Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.5603/rpor.104734

Eduardo Carrasco Solis, Antonella A Anticona Verástegui, J Fernando Márquez Pachas, Alberto E Gonzales-Ccoscco, Cecilia Querevalu Garcia, Yesenia Miranda Tunque, Gustavo Sarria Bardales, Carlos Herrera Castillo, Edward Artemio Meca Castro, José Santa Cruz Delgado, Fernando Carrasco, Ana P Perini, Lucio P Neves, Arthur S B Z Alves, Alessa Maschio, Jhonny Antonio Benavente Castillo, Galo Patino Camargo, William S Santos

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引用次数: 0

Abstract

Background: The application of total body irradiation (TBI), using intensity-modulated techniques with dynamic arcs, creates overlap at the treatment arc boundaries, which can lead to dosimetric variations. Therefore, this research aimed to evaluate the dose distributions in the overlap regions of the arcs used in total body irradiation in pediatric patients.

Material and methods: This dosimetric evaluation was conducted on a CIRS 715-TY0710 pediatric body simulator, where a treatment plan with three isocenters was designed, generating two 4 cm overlap regions along the line connecting the isocenters. The plan was verified using the gamma criteria of 3%/3mm and 5%/5mm with the Octavius 4D software.

Results and conclusions: The planning results showed 98.2% dose coverage over 95% of the planning target volume (PTV) with adequate tolerance for risk organs. Regarding the gamma analysis, the acceptance rate was greater than 95% at the treatment isocenters with criteria of 3%/3 mm and 5%/5 mm. However, there is a decrease in the approved points in the overlap zone when evaluated with a 3%/3 mm criterion, while maintaining an approval percentage above 95% when evaluated with a 5%/5 mm criterion.

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评估在儿科患者全身照射中使用的调制体积弧线重叠区域的剂量分布。

背景：全身照射（TBI）的应用，使用动态弧线的强度调制技术，在治疗弧线边界产生重叠，这可能导致剂量学变化。因此，本研究旨在评估儿科患者全身照射弧线重叠区域的剂量分布。材料与方法：本剂量学评价在CIRS 715-TY0710儿童人体模拟器上进行，该模拟器设计了3个等中心点的治疗方案，在等中心点连接线上产生2个4 cm的重叠区域。利用Octavius 4D软件，采用3%/3mm和5%/5mm的伽马标准对该方案进行了验证。结果与结论：规划结果显示，98.2%的剂量覆盖率超过规划靶体积（PTV）的95%，对危险器官有足够的耐受性。在伽玛分析方面，在治疗等中心，以3%/ 3mm和5%/ 5mm为标准，接受率大于95%。然而，当以3%/ 3mm标准评估时，重叠区域的批准点有所减少，而当以5%/ 5mm标准评估时，批准百分比保持在95%以上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Practical Oncology and Radiotherapy Multiple-

CiteScore

2.80

自引率

8.30%

发文量

115

审稿时长

16 weeks

期刊介绍： Reports of Practical Oncology and Radiotherapy is an interdisciplinary bimonthly journal, publishing original contributions in clinical oncology and radiotherapy, as well as in radiotherapy physics, techniques and radiotherapy equipment. Reports of Practical Oncology and Radiotherapy is a journal of the Polish Society of Radiation Oncology, the Czech Society of Radiation Oncology, the Hungarian Society for Radiation Oncology, the Slovenian Society for Radiotherapy and Oncology, the Polish Study Group of Head and Neck Cancer, the Guild of Bulgarian Radiotherapists and the Greater Poland Cancer Centre, affiliated with the Spanish Society of Radiotherapy and Oncology, the Italian Association of Radiotherapy and the Portuguese Society of Radiotherapy - Oncology.