Intramedullary spinal cord metastasis presenting as the initial manifestation of breast cancer: case report and review of the literature.

IF 0.7 Q4 CLINICAL NEUROLOGY

Spinal Cord Series and Cases Pub Date : 2025-05-07 DOI:10.1038/s41394-025-00708-y

Nadia Bouattour, Sirine Sellami, Yosra Mzid, Slim Charfi, Fatma Hamza, Salma Sakka, Khaireddine Ben Mahfoudh, Amine Bahloul, Mariem Damak

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引用次数: 0

Abstract

Background: Intramedullary spinal cord metastasis (ISCM) is very rare. Symptoms from ISCM metastasis being the initial presentation are extremely rare.

Case presentation: We present a case of a 42-year-old woman without previous medical history who presented with complaints of progressive lower limb weakness of three weeks evolution. Neurological examination elicited a medullary syndrome, and physical examination showed a palpable mass on her right breast. A spinal MRI revealed a dorsal intramedullary tumor mass. A biopsy sample from the breast mass revealed the diagnosis of carcinoma. The diagnosis of an Intramedullary breast cancer metastasis (IMBCM) was made according to positron emission tomography. The patient received treatment with corticosteroids and radiation therapy without improvement, and she died, 3 months after the diagnosis.

Conclusions: As far as we know, this is the first reported case of IMBCM revealing a breast carcinoma. Although extremely rare, ISCM should be considered as a differential diagnosis of a spinal intramedullary lesion.

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以乳腺癌为首发表现的脊髓髓内转移：病例报告及文献复习。

背景：髓内脊髓转移（ISCM）非常罕见。以ISCM转移为最初表现的症状是非常罕见的。病例介绍：我们报告一名42岁无既往病史的女性，以三周进展性下肢无力为主诉。神经学检查提示髓质综合征，体格检查显示右乳可触及肿块。脊柱MRI显示脊背髓内肿瘤肿块。乳房肿块的活组织检查显示为癌。根据正电子发射断层扫描诊断髓内乳腺癌转移（IMBCM）。患者接受了皮质类固醇和放射治疗，但没有改善，在诊断后3个月死亡。结论：据我们所知，这是首次报道的IMBCM显示乳腺癌的病例。尽管极为罕见，ISCM应被视为脊髓髓内病变的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spinal Cord Series and Cases Medicine-Neurology (clinical)

CiteScore

2.20

自引率

8.30%

发文量