Comparison of the effect of cardioplegic solutions used in cardiac surgery on myocardial protection.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.1590/1806-9282.20241451

Mahmut Padak, Reşat Dikme, Ezhar Ersöz, Yasemin Hacanlı

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Abstract

Objective: The aim of this retrospective study was to evaluate the effects of cardioplegic solutions on myocardial protection factors in patients undergoing cardiac surgery with cardiopulmonary bypass and to evaluate the relationship between these effects and early clinical outcomes.

Methods: A total of 78 patients were included in the study. The data of patients who received del Nido cardioplegia (Group 1; n=39) and blood cardioplegia (Group 2; n=39) during the operation were grouped and compared. Preoperative and postoperative routine parameters such as creatine phosphokinase, troponin I, C-reactive protein, and demographic data were recorded, and statistical analyses were performed.

Results: Perfusion time, cross-clamp time, act pump, preoperative C-reactive protein, preoperative creatine phosphokinase, preoperative troponin I, postoperative C-reactive protein, postoperative creatine phosphokinase, postoperative troponin I values were significantly different between del Nido and blood groups (p<0.05).

Conclusion: Del Nido cardioplegia provided myocardial protection and early postoperative favorable results compared to blood cardioplegia, which may make it a viable option for conventional cardiopulmonary bypass.

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心脏手术用截瘫液对心肌保护作用的比较。

目的：本回顾性研究的目的是评估停搏液对心脏手术合并体外循环患者心肌保护因子的影响，并评估这些影响与早期临床预后的关系。方法：共纳入78例患者。del Nido心脏截瘫患者资料(第一组；n=39)和血停搏(2组；N =39)进行分组比较。记录术前和术后常规参数，如肌酸磷酸激酶、肌钙蛋白I、c反应蛋白和人口统计学数据，并进行统计分析。结果：灌注时间、交叉钳夹时间、动作泵、术前c -反应蛋白、术前肌酸磷酸激酶、术前肌钙蛋白I、术后c -反应蛋白、术后肌酸磷酸激酶、术后肌钙蛋白I值在del Nido和不同血型间差异有统计学意义(p)。与血液停搏相比，Del Nido心脏停搏具有心肌保护和术后早期良好的效果，这可能使其成为常规体外循环的可行选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista da Associacao Medica Brasileira (1992)

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