{"title":"Bioreactors as Additive Manufacturing Environments.","authors":"Orkan Telhan","doi":"10.1089/3dp.2024.0023","DOIUrl":null,"url":null,"abstract":"<p><p>This article discusses the evolving use of bioreactors, beyond traditional life sciences and bioengineering, in fields such as architecture, fashion, and product design. It explores the role of bioreactors in additive fabrication, highlighting their distinct characteristics compared with conventional digital manufacturing. The discussion is centered on the differences in materializing biologically-active (living) versus biologically-passive, or biologically-derived (nonliving) matter in which ingredients require closed-loop fabrication environments that differ from traditional additive manufacturing tools. Two novel biofabrication platforms, Microbial Design Studio and B | reactor are presented as examples with case studies demonstrating their use in various manufacturing workflows with live cells. The article emphasizes the unique capabilities of bioreactors in engaging with living matter and facilitating complex interactions between biological, algorithmic, and mechanical systems in additive manufacturing.</p>","PeriodicalId":54341,"journal":{"name":"3D Printing and Additive Manufacturing","volume":"12 2","pages":"169-180"},"PeriodicalIF":2.3000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038321/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"3D Printing and Additive Manufacturing","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1089/3dp.2024.0023","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENGINEERING, MANUFACTURING","Score":null,"Total":0}
引用次数: 0
Abstract
This article discusses the evolving use of bioreactors, beyond traditional life sciences and bioengineering, in fields such as architecture, fashion, and product design. It explores the role of bioreactors in additive fabrication, highlighting their distinct characteristics compared with conventional digital manufacturing. The discussion is centered on the differences in materializing biologically-active (living) versus biologically-passive, or biologically-derived (nonliving) matter in which ingredients require closed-loop fabrication environments that differ from traditional additive manufacturing tools. Two novel biofabrication platforms, Microbial Design Studio and B | reactor are presented as examples with case studies demonstrating their use in various manufacturing workflows with live cells. The article emphasizes the unique capabilities of bioreactors in engaging with living matter and facilitating complex interactions between biological, algorithmic, and mechanical systems in additive manufacturing.
期刊介绍：
3D Printing and Additive Manufacturing is a peer-reviewed journal that provides a forum for world-class research in additive manufacturing and related technologies. The Journal explores emerging challenges and opportunities ranging from new developments of processes and materials, to new simulation and design tools, and informative applications and case studies. Novel applications in new areas, such as medicine, education, bio-printing, food printing, art and architecture, are also encouraged.
The Journal addresses the important questions surrounding this powerful and growing field, including issues in policy and law, intellectual property, data standards, safety and liability, environmental impact, social, economic, and humanitarian implications, and emerging business models at the industrial and consumer scales.
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