Outcomes and management of Peyronie's disease with combined treatment of collagenase clostridium histolyticum, vacuum erection device, and tadalafil.

Raidh Talib Alzubaidi, Mohamed Abdelkareem, Raed M Al-Zoubi, Ahmad R Al-Qudimat, Aksam Yasin, Hatem Kamkoum, Abdullah A Al-Ansari
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Abstract

Abstract: Peyronie's disease (PD) is a connective tissue disorder characterized by abnormal collagen deposition in the tunica albuginea, leading to penile curvature, pain, and erectile dysfunction. This study aimed to evaluate the outcomes of a combined treatment protocol incorporating collagenase clostridium histolyticum (CCH), vacuum erection device, and tadalafil. A retrospective analysis was conducted on 99 male patients with PD treated at the Department of Urology, Hamad Medical Corporation (Doha, Qatar) between January 2018 and January 2020. Patients received 4-8 CCH injections alongside vacuum therapy and daily tadalafil (5 mg). The baseline mean penile curvature of 49.0° improved by an average of 21.4% post-treatment. Erectile function scores also increased significantly, with a mean improvement of 2.3 points on the International Index of Erectile Function. Minor complications were observed in 15 patients, while 13 were dissatisfied with treatment, with six opting for surgery. The modified protocol demonstrated significant improvements in penile curvature and erectile function with minimal complications, offering a safe, cost-effective alternative to traditional intensive treatments.

胶原酶溶组织梭菌、真空勃起装置和他达拉非联合治疗Peyronie病的疗效和治疗
摘要:佩罗尼氏病(PD)是一种结缔组织疾病,其特征是白膜胶原沉积异常,导致阴茎弯曲、疼痛和勃起功能障碍。本研究旨在评估胶原酶溶组织梭菌(CCH)、真空勃起装置和他达拉非联合治疗方案的结果。回顾性分析2018年1月至2020年1月在哈马德医疗公司(卡塔尔多哈)泌尿外科治疗的99例男性PD患者。患者在真空治疗和每日他达拉非(5mg)的同时接受4-8次CCH注射。基线平均阴茎弯曲度为49.0°,治疗后平均改善21.4%。勃起功能评分也显著提高,国际勃起功能指数平均提高2.3分。15例出现轻微并发症,13例对治疗不满意,6例选择手术治疗。改进后的方案在阴茎弯曲度和勃起功能方面有显著改善,并发症最少,提供了传统强化治疗的安全、经济的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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