Quantification of Modifiable Risk Factors in Monoclonal Gammopathy of Undetermined Significance Progression to Multiple Myeloma.

medRxiv : the preprint server for health sciences Pub Date : 2025-04-22 DOI:10.1101/2025.04.21.25326164

Mei Wang, Byron Sigel, Lawrence Liu, John H Huber, Mengmeng Ji, Martin W Schoen, Kristen M Sanfilippo, Theodore S Thomas, Graham A Colditz, Shi-Yi Wang, Su-Hsin Chang

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Abstract

Purpose: Multiple myeloma (MM) is the most common plasma cell dyscrasia in the United States with notably significant health disparities. MM is preceded by an asymptomatic precursor monoclonal gammopathy of undetermined significance (MGUS). Studies have identified several risk factors for the progression of MGUS to MM; however, the relative contributions of these remain unknown. Particularly, understanding the contribution among those modifiable factors may inform MM prevention.

Methods: This study quantified these contributions by estimating the adjusted population attributable fractions (aPAF) of modifiable risk factors for MM among the Veteran population with MGUS.

Results: Among all evaluated risk factors, excess body mass index (BMI ≥25 kg/m ² ) was the leading factor (Black: aPAF=27.0%, 95% CI 19.3-33.9%; White: 27.1%, 95% CI 20.3-33.4%; All: aPAF=27.1%, 95% CI: 22.0-31.8%).

Conclusion: Our study highlights the potential for weight management as a key strategy in reducing the risk of progression to MM in Black and White patients diagnosed with MGUS.

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未确定意义进展为多发性骨髓瘤的单克隆γ病可改变危险因素的量化。

目的：多发性骨髓瘤（MM）是美国最常见的浆细胞病变，存在显著的健康差异。MM之前有一种未确定意义的无症状前体单克隆γ病（MGUS）。研究已经确定了MGUS发展为MM的几个危险因素；然而，这些因素的相对贡献仍然未知。特别是，了解这些可改变因素之间的作用可以为预防MM提供信息。方法：本研究通过估计MGUS退伍军人中MM可变危险因素的调整人群归因分数（aPAF）来量化这些贡献。结果：在所有评估的危险因素中，超重体重指数（BMI≥25 kg/ m2）是主要因素(Black: aPAF=27.0%, 95% CI 19.3-33.9%；白色：27.1%,95% CI 20.3-33.4%；aPAF=27.1%, 95% CI: 22.0-31.8%)。结论：我们的研究强调了体重管理作为降低被诊断为MGUS的黑人和白人患者进展为MM风险的关键策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv : the preprint server for health sciences

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