Bioprosthetic heart valves with zwitterionic copolymer grafting to improve the properties of endothelialization and anti-calcification.

Biomedical materials (Bristol, England) Pub Date : 2025-05-14 DOI:10.1088/1748-605X/add3e7

Daoyang Zhu, Yu Luo, Shenyu Huang, Lie Ma

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Abstract

Heart valve replacement surgery has been the most effective treatment for severe valvular heart disease. Bioprosthetic heart valves (BHVs) crosslinked by glutaraldehyde (GA) have non-negligible advantages in clinical applications. However, structural valve degeneration, calcification, insufficient re-endothelialization and other factors lead to a shortened service life of BHVs. In this study, GA-crosslinked decellularized heart valves (GADHVs) were grafted with zwitterionic copolymer (PSBG) of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide and glycidyl methacrylate, and further treated with Arg-Glu-Asp-Val (REDV) peptide to obtain REDV-PSBG-GADHVs with anti-fouling ability and endothelial cell affinity. REDV-PSBG-GADHVs exhibited good collagen stability, reliable mechanical property and excellent hemocompatibility. Moreover,in vitroandin vivoexperiments demonstrated that REDV-PSBG-GADHVs exhibited better endothelialization property, lower immune responses and reduced calcification than GADHVs. This modified strategy for heart valve fabrication, which can improve the effect of anti-calcification and endothelialization while maintaining the original advantages of BHVs, shows great potential for application in heart valve replacement.

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两性离子共聚物接枝生物人工心脏瓣膜改善内皮化和抗钙化性能。

心脏瓣膜置换术是治疗严重瓣膜性心脏病最有效的方法。戊二醛交联生物人工心脏瓣膜在临床应用中具有不可忽视的优势。然而，瓣膜结构退变、钙化、再内皮化不足等因素导致bhv的使用寿命缩短。本研究将ga交联脱细胞心脏瓣膜（GADHVs）与[2-（甲基丙烯酰氧基）乙基]二甲基-（3-磺基丙基）氢氧化铵和甲基丙烯酸缩水甘油酯两性离子共聚物（PSBG）接枝，并用Arg-Glu-Asp-Val （REDV）肽进行处理，得到具有抗脏能力和内皮细胞亲和力的REDV-PSBG-GADHVs。REDV-PSBG-GADHVs具有良好的胶原稳定性、可靠的力学性能和优良的血液相容性。此外，体外实验表明，与GADHVs相比，REDV-PSBG-GADHVs具有更好的内皮化特性，更低的免疫反应和更少的钙化。这种改良的心脏瓣膜制造策略在保持bhv原有优势的同时，提高了抗钙化和内皮化的效果，在心脏瓣膜置换术中具有很大的应用潜力。

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Biomedical materials (Bristol, England)

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