[Elevated neutrophil-lymphocyte ratio and delayed graft function].

Itzy Maely Gaytán-Campos, Aurelio Chávez-Meza, José Oscar Juaréz-Sánchez, Yumar Alfredo Hurtado-Castillo, Rafael Luna-Montalbán, Martha Alicia Hernández-González
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Abstract

Background: Delayed graft function (DGF) is a significant complication in kidney transplantation, adversely affecting graft and recipient survival. Therefore, it is important to establish tools that help predict this condition. The elevation of the neutrophil-to-lymphocyte ratio (NLR) has been studied as a predictor of DGF, with the premise that its increase is associated with systemic inflammation and, consequently, DGF.

Objective: To analyze the association between an elevated NLR in the preoperative period and delayed graft function in kidney transplant recipients.

Materials and methods: A prospective, observational, analytical, and longitudinal study. The sample included all patients admitted to the Nephrology Transplant Service at Hospital de Especialidades No. 1, Centro Médico Nacional Bajío, in 2023.

Results: We found that an NLR greater than 3.5 in the preoperative period of patients undergoing kidney transplantation had 80% specificity and 28% sensitivity, compared to patients with an NLR of 3.5 or lower.

Conclusions: There is no association between an elevated NLR in the preoperative period and delayed kidney graft function after transplantation. However, it may be associated with other risk factors, as demonstrated in the multivariate analysis, which revealed that donor acute kidney injury increased the likelihood of developing DGF by almost 200%.

中性粒细胞/淋巴细胞比例升高和移植物功能延迟。
背景:移植功能延迟(DGF)是肾移植的重要并发症,对移植物和受体的生存产生不利影响。因此,建立有助于预测这种情况的工具是很重要的。中性粒细胞与淋巴细胞比值(NLR)的升高已被研究作为DGF的预测因子,前提是其升高与全身性炎症有关,因此与DGF有关。目的:分析肾移植受者术前NLR升高与移植功能延迟的关系。材料和方法:前瞻性、观察性、分析性和纵向研究。样本包括2023年在第一医院(Centro m国家中心Bajío)肾移植服务中心住院的所有患者。结果:我们发现,与NLR为3.5或更低的患者相比,术前NLR大于3.5的肾移植患者的特异性为80%,敏感性为28%。结论:术前NLR升高与移植后肾功能延迟无相关性。然而,多变量分析表明,它可能与其他危险因素有关,该分析显示,供体急性肾损伤使发生DGF的可能性增加了近200%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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