Surgery Versus Chemoradiation Therapy for Oropharyngeal Squamous Cell Carcinoma: A Multidimensional Cross-Sectional Study.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Diseases (Basel, Switzerland) Pub Date : 2025-04-02 DOI:10.3390/diseases13040106

Giuseppe Riva, Dario Gamba, Simone Moglio, Giuseppe Carlo Iorio, Chiara Cavallin, Umberto Ricardi, Mario Airoldi, Andrea Canale, Andrea Albera, Giancarlo Pecorari

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Abstract

Background/objectives: The management of oropharyngeal squamous cell carcinoma (OPSCC) often involves multidisciplinary decision-making to optimize patient outcomes. Surgery and chemoradiation therapy (CRT) represent the two main treatment modalities. The aim of this cross-sectional study was to provide a comprehensive analysis of quality of life, speech, swallowing, sleep, psychological distress, and nutritional status in OPSCC patients treated with either surgery or CRT.

Methods: Thirty subjects were divided into two groups based on treatment modality (>12-month follow-up): (A) surgery ± adjuvant treatment (15 patients); (B) exclusive CRT (15 patients). A multidimensional evaluation was performed by means of validated questionnaires. The following parameters were analyzed: quality of life, speech, swallowing, sleep quality, risk of sleep apnea, sleepiness, psychological distress, pain, and nutritional status.

Results: No statistically significant difference was found between the two study groups for every parameter. The EORTC QLQ-C30 globally showed a good quality of life in both groups. Poor sleep quality was observed in 9 (60%) subjects in group A and in 6 (40%) patients in group B, respectively. Low, intermediate and high risk of malnutrition was observed in 73.3%, 20.0% and 6.7% of cases in group A, and in 93.3%, 6.7% and 0.0% in group B, respectively.

Conclusions: Surgery and exclusive chemoradiotherapy appear to yield similar long-term outcomes across all evaluated dimensions, including quality of life, speech, swallowing, sleep, psychological distress, and nutritional status.

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口咽鳞状细胞癌的手术与放化疗：一项多维横断面研究。

背景/目的：口咽鳞状细胞癌（OPSCC）的治疗通常涉及多学科决策以优化患者预后。手术和放化疗（CRT）是两种主要的治疗方式。本横断面研究的目的是对手术或CRT治疗的OPSCC患者的生活质量、言语、吞咽、睡眠、心理困扰和营养状况进行全面分析。方法：30例患者按治疗方式分为两组（随访12个月）：(A)手术±辅助治疗（15例）；(B)单独CRT（15例）。通过有效问卷进行多维度评价。分析以下参数：生活质量、言语、吞咽、睡眠质量、睡眠呼吸暂停风险、嗜睡、心理困扰、疼痛和营养状况。结果：两组间各参数均无统计学差异。在全球范围内，两组的EORTC QLQ-C30都显示出良好的生活质量。A组有9例（60%）睡眠质量差，B组有6例（40%）睡眠质量差。A组低、中、高营养不良发生率分别为73.3%、20.0%和6.7%，B组为93.3%、6.7%和0.0%。结论：手术和单纯放化疗似乎在所有评估维度上产生相似的长期结果，包括生活质量、言语、吞咽、睡眠、心理困扰和营养状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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