Perceived Control, Cognitive Training, and Incident Alzheimer's Disease and Related Dementias in the ACTIVE study.

IF 4.8 2区医学 Q1 GERIATRICS & GERONTOLOGY

Journals of Gerontology Series B-Psychological Sciences and Social Sciences Pub Date : 2025-05-02 DOI:10.1093/geronb/gbaf086

Laura B Zahodne, Katherine Miller, Chuxuan Sun, Neika Sharifian, Jeanine M Parisi, George W Rebok, Adrienne T Aiken Morgan, Alden L Gross, Kelsey R Thomas, Cynthia Felix, Norma B Coe

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引用次数: 0

Abstract

Objectives: Greater perception of control over important life outcomes has been linked to better cognitive performance and greater benefits from cognitive training interventions among older adults. However, it is not yet known whether perceived control predicts incident Alzheimer's disease and related dementias (ADRD) or influences links between cognitive training and ADRD incidence.

Methods: Data were obtained from 2,021 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial. Baseline perceived control was measured with the Personality in Intellectual Aging Contexts Inventory. Incident diagnosed ADRD over 20 years was operationalized using the Centers for Medicare and Medicaid Services claims data. Main effects of perceived control and interactions between perceived control and intervention group (reasoning, memory, speed, control) on diagnosed ADRD incidence were estimated using cause-specific hazard models.Results: Greater perceived control at study baseline was associated with reduced hazard of ADRD. Perceived control did not moderate associations between intervention group and time to ADRD diagnosis.

Discussion: Strengthening perceived control through individual and/or environmental interventions may lower ADRD risk.

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ACTIVE研究中的感知控制、认知训练和阿尔茨海默病及相关痴呆的发生率

目的：老年人对重要生活结果的更强的控制感与更好的认知表现和从认知训练干预中获得的更大益处有关。然而，尚不清楚感知控制是否能预测阿尔茨海默病和相关痴呆（ADRD）的发生，或影响认知训练和ADRD发病率之间的联系。方法：数据来自独立和重要老年人高级认知训练（ACTIVE）试验的2021名参与者。基线知觉控制用智力老化背景人格量表测量。使用医疗保险和医疗补助服务中心的索赔数据，对20多年来诊断为ADRD的事件进行了操作。采用原因特异性风险模型估计感知控制以及感知控制与干预组（推理、记忆、速度、控制）之间的相互作用对ADRD诊断发生率的主要影响。结果：在研究基线时，更好的感知控制与减少ADRD的危险相关。感知控制在干预组与ADRD诊断时间之间无中度相关性。讨论：通过个人和/或环境干预加强感知控制可能降低ADRD风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journals of Gerontology Series B-Psychological Sciences and Social Sciences 医学-老年医学

CiteScore

11.60

自引率

8.10%

发文量

178

审稿时长

6-12 weeks

期刊介绍： The Journal of Gerontology: Psychological Sciences publishes articles on development in adulthood and old age that advance the psychological science of aging processes and outcomes. Articles have clear implications for theoretical or methodological innovation in the psychology of aging or contribute significantly to the empirical understanding of psychological processes and aging. Areas of interest include, but are not limited to, attitudes, clinical applications, cognition, education, emotion, health, human factors, interpersonal relations, neuropsychology, perception, personality, physiological psychology, social psychology, and sensation.