A Patient-Customized Oral Appliance to Prevent Trismus and Improve Salivary Function in Head and Neck Cancer Survivors.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-05-07 DOI:10.1002/hed.28183

Allan Chung, Yu-Ting Chung, Fu-Yuan Teng, Wei-Ruei Li, Te-Chin Lo, Yo-Wen Liang, Yih-Lin Chung

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引用次数: 0

Abstract

Background: Chemoradiotherapy for head and neck cancer often causes trismus and xerostomia-induced dental caries, impairing quality of life. Current interventions have compliance and efficacy issues. This study developed a patient-customized oral appliance to address both conditions.

Methods: A fluoride delivery appliance was designed using an interactive approach and decision-matrix scoring. A longitudinal clinical study (n = 30) evaluated its impact on mouth opening, salivary flow, and patient-reported outcomes.

Results: The final design featured a posterior occlusal support, enhancing mandibular mobility and fluoride delivery. At 5 years postradiotherapy, benefits included improved saliva flow, reduced dental caries, pain-free full mouth opening, and enhanced eating and speaking functions. The Gothenburg Trismus Questionnaire scores indicated superior recovery over standard fluoride trays (p = 0.0002).

Conclusions: This novel oral appliance offers a dual-function, patient-customized approach to improving mandibular mobility and salivary function, ultimately enhancing long-term quality of life for head and neck cancer survivors after chemoradiotherapy.

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患者定制口腔矫治器预防头颈癌幸存者牙关紧闭和改善唾液功能。

背景：头颈癌放化疗常导致牙关和口干性龋齿，影响患者的生活质量。目前的干预措施存在依从性和有效性问题。本研究开发了一种患者定制的口腔矫治器来解决这两种情况。方法：采用交互法和决策矩阵评分法设计氟化物输送器。一项纵向临床研究（n = 30）评估了其对口腔张开、唾液流动和患者报告结果的影响。结果：最终设计的特点是后牙合支持，增强下颌活动和氟化物输送。在放疗后5年，益处包括改善唾液流动，减少龋齿，无痛全口张开，增强进食和说话功能。哥德堡牙关问卷得分表明，与标准氟化物托盘相比，回收率更高（p = 0.0002）。结论：这种新型口腔矫治器提供了一种双重功能，患者定制的方法来改善下颌活动和唾液功能，最终提高头颈癌化疗后幸存者的长期生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.