Evaluation of the Efficacy of Electroconvulsive Therapy in Relation to the Anesthetic Agent Applied: A Retrospective Analysis.

IF 1.8 4区医学 Q3 BEHAVIORAL SCIENCES

Journal of Ect Pub Date : 2025-04-28 DOI:10.1097/YCT.0000000000001155

Selin Balki Tekin, Ayşe Nur İnci Kenar, İhsan Anıl Doğruyol, Özgür Tekin

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引用次数: 0

Abstract

Objectives: The present study aims to make a contribution to the extant literature on the sharing of clinical experiences with electroconvulsive therapy (ECT) and the effects of different anesthetic drugs on ECT efficacy.

Methods: A retrospective analysis of the medical records of patients who were administered ECT from March 2023 to July 2024 was conducted to obtain data on age, gender, psychiatric diagnosis, type of psychiatric drugs used, the effectiveness of ECT, type of anesthetic agent administered during ECT, and the side effects after ECT.

Results: A total of 149 patients were included in the study, of whom 81 (54.4%) were female and 68 (45.6%) were male, with a mean age of 41.72 years (±15.68). At least 1 side effect related to ECT was reported in 23 patients. When the number of effective sessions was analyzed according to the anesthetic agent used, the number of effective sessions of ECT was statistically significantly higher in patients who received ketamine alone than in patients who received propofol, propofol to ketamine, and propofol ketamine combination (P < 0.001, P < 0.001, P = 0.011, respectively). No significant relationship was found between the type of anesthetic agent and side effects (P = 0.059).

Conclusions: The combination of ketamine and propofol may be regarded as a safer option in terms of side effects and cognitive functions when compared with their use in isolation. Furthermore, the utilization of ketamine as an anesthetic agent in patients exhibiting ineffective seizures can be regarded as a viable alternative strategy.

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电惊厥治疗与所用麻醉剂的疗效评价：回顾性分析。

目的：本研究旨在为电痉挛治疗（ECT）的临床经验及不同麻醉药物对ECT疗效的影响的文献分享做出贡献。方法：回顾性分析2023年3月至2024年7月接受电痉挛治疗的患者的病历资料，包括年龄、性别、精神科诊断、使用精神科药物类型、电痉挛疗效、电痉挛期间使用麻醉剂类型、电痉挛后副作用等。结果：共纳入149例患者，其中女性81例（54.4%），男性68例（45.6%），平均年龄41.72岁（±15.68）。23例患者报告了至少1个与ECT相关的副作用。根据使用的麻醉剂进行有效次数分析时，单独使用氯胺酮组ECT有效次数明显高于异丙酚组、异丙酚与氯胺酮组、异丙酚与氯胺酮联用组（P < 0.001, P < 0.001, P = 0.011）。麻醉药物种类与不良反应无显著相关（P = 0.059）。结论：与单独使用相比，氯胺酮和异丙酚联用在副作用和认知功能方面可能被认为是一种更安全的选择。此外，使用氯胺酮作为麻醉剂的患者表现出无效的癫痫发作可以被视为一个可行的替代策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ect 医学-行为科学

CiteScore

3.70

自引率

20.00%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The Journal of ECT covers all aspects of contemporary electroconvulsive therapy, reporting on major clinical and research developments worldwide. Leading clinicians and researchers examine the effects of induced seizures on behavior and on organ systems; review important research results on the mode of induction, occurrence, and propagation of seizures; and explore the difficult sociological, ethical, and legal issues concerning the use of ECT.