BDNF Gene Polymorphism and Antidepressant Response in Han Chinese Patients with First-Episode Late-Life Depression.

IF 1.3 Q3 PSYCHIATRY
Alpha psychiatry Pub Date : 2025-04-24 eCollection Date: 2025-04-01 DOI:10.31083/AP39955
Han Wu, Jiao-Jiao Zhou, Xue-Yan Chen, Dan-di Zhu, Feng Bao, Wei Zheng, Li Ren, Wei-Gang Pan, Chao-Meng Liu
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Abstract

Objective: This study investigated the association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and antidepressant response in patients with first-episode late-life depression (LLD).

Methods: A total of 72 patients with first-episode LLD were recruited and 57 completed an 8-week course of antidepressant treatment. Participants were assessed at baseline and post-treatment using the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum BDNF levels were measured via Enzyme-Linked Immunosorbent Assay (ELISA) and BDNF gene polymorphisms were genotyped using the Agena® MassARRAY system.

Results: After 8 weeks, 17 of the 57 patients with LLD showed effective treatment response (effective group), while 40 were classified as ineffective. Significant post-treatment improvements were observed across the cohort in HAMD-17 and RBANS scores, and serum BDNF levels compared with baseline (p < 0.05). However, the effective and ineffective groups did not have significantly different RBANS scores or serum BDNF levels (p > 0.05). Binary logistic regression identified male sex (OR = 10.094, p = 0.007) and BDNF gene polymorphism (OR = 6.559, p = 0.003) as predictors of treatment efficacy.

Conclusion: Antidepressant treatment for 8 weeks altered serum BDNF levels in patients with LLD, with male patients carrying the Val/Val genotype potentially responded better to conventional antidepressants. The small sample size may limit the generalizability of these findings.

Clinical trial registration: The study was registered at https://www.chictr.org.cn (registration number: ChiCTR1900024445).

汉族首发晚期抑郁症患者BDNF基因多态性与抗抑郁反应
目的:探讨脑源性神经营养因子(BDNF)基因多态性与首发晚期抑郁症(LLD)患者抗抑郁反应的关系。方法:共招募72例首发LLD患者,其中57例完成了为期8周的抗抑郁治疗。参与者在基线和治疗后使用17项汉密尔顿抑郁评定量表(HAMD-17)和神经心理状态评估可重复电池(rban)进行评估。通过酶联免疫吸附试验(ELISA)检测血清BDNF水平,并使用Agena®MassARRAY系统对BDNF基因多态性进行基因分型。结果:治疗8周后,57例LLD患者中,有效组17例,无效组40例。与基线相比,整个队列在HAMD-17和rban评分以及血清BDNF水平方面观察到显著的治疗后改善(p < 0.05)。而有效组和无效组的rban评分和血清BDNF水平无显著差异(p < 0.05)。二元logistic回归发现男性性别(OR = 10.094, p = 0.007)和BDNF基因多态性(OR = 6.559, p = 0.003)是治疗效果的预测因子。结论:抗抑郁药物治疗8周改变了LLD患者血清BDNF水平,携带Val/Val基因型的男性患者对常规抗抑郁药物的反应可能更好。小样本量可能限制了这些发现的普遍性。临床试验注册:本研究注册于https://www.chictr.org.cn(注册号:ChiCTR1900024445)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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