Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns.

IF 3.6 Q2 TOXICOLOGY
Frontiers in toxicology Pub Date : 2025-04-29 eCollection Date: 2025-01-01 DOI:10.3389/ftox.2025.1572486
Antonin Ambroz, Jiri Klema, Andrea Rossnerova, Alena Milcova, Anna Pastorkova, Jana Pulkrabova, Ondrej Parizek, Veronika Gomersall, Tomas Gramblicka, Jaroslav Zelenka, Tomas Ruml, Nikola Vrzackova, Milos Veleminsky, Newroz Hasan, Jan Topinka, Radim J Sram, Pavel Rossner
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引用次数: 0

Abstract

The aim of the study was to analyze the variables that modify the levels of oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns from environmentally distinct localities of the Czech Republic: Ceske Budejovice (CB, an agricultural region) and Karvina (an industrial region). Personal, socio-economic and medical data, concentrations of particulate matter of aerodynamic diameter < 2.5 µm (PM2.5) and benzo[a]pyrene (B[a]P) in the ambient air, the activities of antioxidant mechanisms (superoxide dismutase, catalase, glutathione peroxidase) and antioxidant capacity), the levels of pro-inflammatory cytokines, the concentrations of persistent organic pollutants (POPs) in blood plasma/cord blood plasma and urinary levels of polycyclic aromatic hydrocarbons metabolites (OH-PAHs) were investigated as parameters potentially affecting the markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxodG) and lipid peroxidation (15-F2t-isoprostane, 15-F2t-IsoP). Significantly higher levels of POPs were detected in the plasma of mothers/newborns from CB (p < 0.001), while increased external levels of B[a]P and PM2.5, confirmed by analyzing urinary OH-PAHs, were found in Karvina subjects (p < 0.001). In mothers, multivariate analysis showed no significant difference in oxidative stress markers (15-F2t-IsoP, 8-oxodG) between the two localities. The analysis further revealed that neither in CB nor, unexpectedly, in Karvina, did PAH exposure affect maternal lipid peroxidation. Significant associations between OH-PAHs and 15-F2t-IsoP or 8-oxodG were observed only in newborns. In addition, multivariate analyses revealed a borderline significant association between locality and 8-oxodG in the urine of all newborns (p = 0.05). In conclusion, not only the maternal exposure of PAHs but also some POPs can negatively affect oxidative stress status in the early-life of newborns.

环境污染与孕妇和新生儿促氧化、抗氧化和炎症标志物的关系。
该研究的目的是分析来自捷克共和国环境不同地区的不吸烟母亲及其新生儿的氧化DNA损伤和脂质过氧化水平的变量:Ceske Budejovice (CB,农业区)和Karvina(工业区)。个人、社会经济和医疗数据、空气动力学直径< 2.5µm的颗粒物(PM2.5)和环境空气中苯并[a]芘(B[a]P)的浓度、抗氧化机制(超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶)的活性和抗氧化能力、促炎细胞因子的水平、研究了血浆/脐带血中持久性有机污染物(POPs)浓度和尿液中多环芳烃代谢物(OH-PAHs)水平作为可能影响DNA氧化(8-氧-7,8-二氢-2'-脱氧鸟苷,8-氧- g)和脂质过氧化(15- f2t -异前列腺素,15-F2t-IsoP)标志物的参数。母亲/新生儿血浆中持久性有机污染物(POPs)的含量显著升高(p < 0.001),而Karvina受试者体内的B[a] p和PM2.5的外部含量升高(p < 0.001),通过分析尿液中OH-PAHs证实了这一点。在母亲中,多变量分析显示两个部位的氧化应激标志物(15-F2t-IsoP, 8-oxodG)无显著差异。分析进一步显示,无论是在CB还是Karvina, PAH暴露都没有影响母体脂质过氧化。仅在新生儿中观察到OH-PAHs与15-F2t-IsoP或8-oxodG之间的显著关联。此外,多变量分析显示,所有新生儿的尿中8-oxodG与地点之间存在显著的关联(p = 0.05)。综上所述,母亲接触多环芳烃不仅会对新生儿早期氧化应激状态产生负面影响,某些持久性有机污染物也会对新生儿早期氧化应激状态产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
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审稿时长
13 weeks
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