Relationship between MTHFR, MTRR gene polymorphisms and H-type hypertension: a systematic review and meta-analysis.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-04-21 DOI:10.1080/03014460.2025.2486165

Lan Gao, Lisen Dong, Yixuan Niu, Meiyun Jian, Junli Yang, Gang Chen, Hailang Tang, Changhai Su, Lei Xu

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引用次数: 0

Abstract

Context: The relationship between methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms and H-type hypertension susceptibility has been deeply analysed, but the conclusions are not consistent. Therefore, we carried out a meta-analysis aimed at assessing the relationship exactly.

Methods: Six English databases (PubMed, Embase, EBSCO, ScienceDirect, Cochrane Library, and Web of Science) and four Chinese databases (China Biological Medicine, WanFang, China Science and Technology Journal, and China National Knowledge Infrastructure) were used for searching studies from inception to August 2023. MTHFR C677T/A1298C and MTRR A66G genetic polymorphisms were evaluated.

Results: A total of 24 papers were included in our research, including 3649 H-type hyperpietics, 2772 non-H-type hyperpietics, and 2149 healthy controls. Our analysis shows that MTHFR C677T polymorphism showed significant association with H-type hypertension in both healthy individuals and non-H-type hyperpietics (TT vs. CC: OR = 3.43, 95% CI = 2.48-4.75). Further subgroup analysis based on geography revealed that homocysteine levels in the southern Chinese population were more susceptible to MTHFR C677T polymorphism (p < 0.05). However, there was no significant association in all genetic models for the polymorphisms of MTHFR A1298C and MTRR A66G.

Conclusion: MTHFR C677T polymorphisms are associated with H-type hypertension in non-H-type hyperpietics and healthy individuals.

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MTHFR、MTRR基因多态性与h型高血压的关系：系统综述和荟萃分析

背景：亚甲基四氢叶酸还原酶（MTHFR）和蛋氨酸合成酶还原酶（MTRR）基因多态性与h型高血压易感性的关系虽有深入分析，但结论并不一致。因此，我们进行了一项旨在准确评估两者关系的荟萃分析。方法：使用6个英文数据库（PubMed、Embase、EBSCO、ScienceDirect、Cochrane Library和Web of Science）和4个中文数据库（中国生物医学、万方、中国科技杂志和中国国家知识基础设施）检索从成立到2023年8月的研究。MTHFR C677T/A1298C和MTRR A66G遗传多态性进行了评价。结果：共纳入24篇论文，其中h型高血压患者3649篇，非h型高血压患者2772篇，健康对照2149篇。我们的分析显示MTHFR C677T多态性与健康个体和非h型高血压患者的h型高血压有显著相关性（TT vs. CC: OR = 3.43, 95% CI = 2.48-4.75）。进一步基于地理的亚组分析显示，中国南方人群的同型半胱氨酸水平更容易受到MTHFR C677T多态性的影响(p)。结论：MTHFR C677T多态性与非h型高血压和健康个体的h型高血压有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.