Unlocking the Power of Electrospinning: A Review of Cutting-Edge Polymers and their Impact on Scaffold Design and Performance.

Tanmoy Ghosh, Aditya Nemadea, Vineeth Kumar K, Shruthi N, Shwetha V, Pushpalatha C
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Abstract

Electrospun scaffolds are pivotal in tissue engineering due to their ability to mimic the Extracellular Matrix (ECM). Despite their potential, challenges such as, two-dimensional structure, limited load bearing capacity, and low mechanical strength restrict their application. This review explores advancements in electrospinning techniques and materials, highlighting methods like coaxial electrospinning, which enables the encapsulation of therapeutic agents, and the integration with 3D printing to create hybrid scaffolds with improved cell infiltration. Characterization techniques assessed by different researchers, such as scaffold morphology, mechanical properties, and biocompatibility, show that scaffolds with high spatial interconnectivity and controlled alignment enhance cell orientation and migration. Innovations in smart polymers and stimuli-responsive materials have furthered scaffold functionality. While recent advancements address some limitations, issues with scalability and production uniformity remain. Future research should optimize fabrication parameters and explore novel materials to enhance scaffold performance, requiring collaborative efforts and technological innovations to expand their practical applications in tissue engineering and regenerative medicine.

解锁静电纺丝的力量:回顾尖端聚合物及其对支架设计和性能的影响。
电纺丝支架由于其模拟细胞外基质(ECM)的能力而在组织工程中起着关键作用。尽管它们具有潜力,但诸如二维结构,有限的承载能力和低机械强度等挑战限制了它们的应用。本文探讨了静电纺丝技术和材料的进展,重点介绍了同轴静电纺丝等方法,该方法可以实现治疗剂的封装,并与3D打印相结合,以创建具有改善细胞浸润的混合支架。不同研究人员评估的表征技术,如支架形态、力学性能和生物相容性,表明具有高空间互联性和可控排列的支架可以增强细胞的取向和迁移。智能聚合物和刺激响应材料的创新进一步提高了支架的功能。虽然最近的进步解决了一些限制,但可扩展性和生产一致性的问题仍然存在。未来的研究应优化制造参数,探索新型材料,以提高支架的性能,需要共同努力和技术创新,以扩大其在组织工程和再生医学中的实际应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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