The University of Florida Dermatopathology Experience With the Pigmented Lesion Assay.

IF 1.1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI:10.1097/DAD.0000000000002974

Elaine Kunzler, Clinton Enos, Mary Bohannon, Addie Walker, Leah Hooey, Tricia Missall, Kiran Motaparthi, Vladimir Vincek

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引用次数: 0

Abstract

Abstract: The pigmented lesion assay (PLA) is a noninvasive test used to risk stratify pigmented lesions and rule out melanoma. There is a scarcity of data from nonbiased studies on PLA performance in the real world. PLA results from 107 skin specimens were compared with final pathologic diagnoses. To determine clinical relevance of PLA results, diagnoses were categorized into actionable melanocytic, nonactionable melanocytic, and nonmelanocytic. Of specimens with positive PLA results, 24.0% (25/104) were actionable melanocytic diagnoses, 42.3% (44/104) nonactionable melanocytic, and 33.7% (35/104) nonmelanocytic. Because most specimens submitted for pathologic evaluation had positive PLA results, positive predictive values were calculated for overall PLA results and the individual genes tested. The overall positive predictive value for surgically actionable melanocytic lesions was 24.0%. The positive predictive values of the individual genes were determined to be 28.2% for LINC00518, 34.7% for PReferentially expressed Antigen in Melanoma, and 31.8% for telomerase reverse transcriptase.

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佛罗里达大学皮肤病理学的经验与色素病变化验。

摘要：色素沉着病变试验（PLA）是一种无创检测方法，用于对色素沉着病变进行风险分层并排除黑色素瘤。在现实世界中，关于解放军表现的无偏见研究数据缺乏。对107例皮肤标本的PLA结果进行最终病理诊断的比较。为了确定PLA结果的临床相关性，诊断分为可动性黑素细胞、不可动性黑素细胞和非黑素细胞。在PLA阳性的标本中，24.0%（25/104）诊断为可行动的黑色素细胞，42.3%（44/104）诊断为不可行动的黑色素细胞，33.7%（35/104）诊断为非黑色素细胞。由于大多数提交病理评估的标本PLA结果呈阳性，因此计算PLA总体结果和单个基因检测的阳性预测值。手术可操作的黑素细胞病变的总体阳性预测值为24.0%。LINC00518阳性预测值为28.2%，黑色素瘤中优先表达抗原阳性预测值为34.7%，端粒酶逆转录酶阳性预测值为31.8%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians