Xiang-Xiang Yang, Hui Luo, Jia-Jun Zhang, Heng Ge, Liang Ge
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引用次数: 0
Abstract
Ultra-high dose rate flash radiotherapy (FLASH-RT) has attracted wide attention in the field of radiotherapy in recent years. For FLASH-RT, radiation is delivered at a very high dose rate [usually thousands of times compared with conventional radiotherapy (CONV-RT)] in an extremely short time. This novel irradiation technique shows a protective effect on normal tissues, also known as the flash effect. At the same time, FLASH-RT is comparable to CONV-RT in terms of tumor-killing efficacy. As basic research dedicates to uncover the mechanisms by which FLASH-RT reduces radiation-induced normal tissue damage, clinical trials of FLASH-RT have been gradually conducted worldwide. This article systematically reviews the evidence of the feasibility and safety of FLASH-RT in clinical practice and offers insights into the future translation of this technology in clinic.
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