A Promising Route for Established Indications: A Systematic Review of Nebulized Ketamine in Pain.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Current Pain and Headache Reports Pub Date : 2025-04-30 DOI:10.1007/s11916-025-01394-z

Neveen A Kohaf, Tabia Imtiyaz Khan, Hamada Hamdy Elbana, Ro'a Azzam Hassouna, Mohamed Maher Abd Elfattah, Prashant Nasa, Sahar Shekoohi, Alan David Kaye, Islam Mohammad Shehata

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Abstract

Background: Nebulized ketamine, an innovative route of drug delivery, has gained interest for its potential effectiveness in challenging clinical scenarios. The objective of this systematic review is to provide insights into the safety and effectiveness of nebulized ketamine in pain management.

Method: A systematic search was performed on online databases including WOS, Cochrane, Scopus, and PubMed, using a specific search strategy. Our review focused on primary studies about the utilization of nebulized ketamine in various contexts regarding pain management. Additionally, we incorporated relevant secondary research, such as reviews presenting diverse perspectives.

Results: Nebulized ketamine in pain management included nine studies.

Conclusion: The advantages of nebulized ketamine over other forms of administration include its rapid absorption and effective delivery. The smaller volume required for nebulization can result in fewer side effects and enhanced patient compliance thereby facilitating efficient drug delivery while minimizing the systematic impact. Emerging evidence supports the administration of nebulized ketamine as a safe and efficacious treatment for acute pain. However, further investigations are needed for a better understanding of its pharmacokinetics, optimal dosing and efficacy across different populations.

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建立适应症的有希望的途径：雾化氯胺酮治疗疼痛的系统综述。

背景：氯胺酮雾化给药是一种创新的给药途径，因其在具有挑战性的临床场景中的潜在有效性而引起了人们的兴趣。本系统综述的目的是为雾化氯胺酮在疼痛管理中的安全性和有效性提供见解。方法：采用特定的检索策略，对WOS、Cochrane、Scopus、PubMed等在线数据库进行系统检索。我们的综述集中在关于雾化氯胺酮在疼痛管理的各种情况下的应用的初步研究。此外，我们还纳入了相关的二次研究，例如不同观点的评论。结果：氯胺酮雾化治疗疼痛纳入9项研究。结论：氯胺酮雾化给药具有吸收快、给药有效等优点。雾化所需的较小体积可以减少副作用，提高患者依从性，从而促进有效的药物输送，同时最大限度地减少对系统的影响。新出现的证据支持氯胺酮雾化作为急性疼痛安全有效的治疗方法。然而，需要进一步的研究来更好地了解其药代动力学、最佳剂量和不同人群的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.