Correlational Analysis of Resistant Hypertension with Diabetes Mellitus, Chronic Kidney Disease, and the Interplay of Sodium, Calcium, Magnesium, and Phosphorus.

IF 2.8 Q2 PERIPHERAL VASCULAR DISEASE

Vascular Health and Risk Management Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI:10.2147/VHRM.S504454

Xin-Di Feng, Shao-Feng Wang, Si-Yu Qiao, Jia-Ying Huang, Zi-Lin Ma, Duan Zhou, Jing-Yi Tang, Yi-Hong Wei

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Abstract

Objective: To analyze the relationship between resistant hypertension (RH) and hypertension, diabetes mellitus, chronic kidney disease, sodium, calcium, magnesium, phosphorus.

Methods: A total of 475 patients with hypertension admitted to Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2021 to December 2023 were divided into hypertension group (HT group) and resistant hypertension group (RH group). We compared the differences between these two groups, and analyzed the influencing factors of RH, as well as the correlation between RH and the course of hypertension, diabetes mellitus, chronic kidney disease, and levels of sodium, calcium, magnesium and phosphorus.

Results: Compared with HT group, RH group had a significantly higher blood pressure (P < 0.05), longer duration of hypertension, diabetes mellitus, and chronic kidney disease (P < 0.01) and a higher proportion of combined chronic kidney disease (P = 0.006). The duration of hypertension, serum sodium ion concentration (≥142.00 mmol/L), calcium ion concentration (2.19 to < 2.30 mmol/L), and 24h urinary phosphorus ion level were independent influencing factors of RH (P < 0.05).

Conclusion: For hypertension patients with diabetes mellitus or chronic kidney disease, the risk of RH is significantly higher. The risk of RH may be lower in patients with blood sodium <142.00 mmol/L, blood calcium >2.29 mmol/L, 24h urine sodium and magnesium ions of 116.52 and 2.69 mmol, respectively, and higher 24h urine phosphorus ions.

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顽固性高血压与糖尿病、慢性肾病的相关性分析及钠、钙、镁、磷的相互作用。

目的：分析顽固性高血压（RH）与高血压、糖尿病、慢性肾病、钠、钙、镁、磷的关系。方法：将2021年1月至2023年12月上海中医药大学附属龙华医院收治的高血压患者475例分为高血压组（HT组）和顽固性高血压组（RH组）。比较两组患者的差异，分析RH的影响因素，以及RH与高血压、糖尿病、慢性肾病病程、钠、钙、镁、磷水平的相关性。结果：与HT组相比，RH组患者血压明显升高（P < 0.05），高血压、糖尿病、慢性肾脏疾病病程延长（P < 0.01），合并慢性肾脏疾病比例较高（P = 0.006）。高血压持续时间、血清钠离子浓度（≥142.00 mmol/L）、钙离子浓度（2.19 ~ < 2.30 mmol/L）、24h尿磷离子水平是RH的独立影响因素（P < 0.05）。结论：合并糖尿病或慢性肾病的高血压患者发生RH的风险明显增高。血钠2.29 mmol/L， 24h尿钠、镁离子分别为116.52、2.69 mmol， 24h尿磷离子较高的患者RH风险较低。

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来源期刊

Vascular Health and Risk Management PERIPHERAL VASCULAR DISEASE-

CiteScore

4.20

自引率

3.40%

发文量

109

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention, and treatment of vascular disease and its sequelae; and the involvement of metabolic disorders, particularly diabetes. In addition, the journal will also seek to define drug usage in terms of ultimate uptake and acceptance by the patient and healthcare professional.