Impact of Physical Activity Levels on Parkinson's Disease Motor and Nonmotor Symptoms and Quality of Life in Older Adults With Parkinson's Disease.

IF 1.4 4区医学 Q4 GERIATRICS & GERONTOLOGY

Journal of Aging and Physical Activity Pub Date : 2025-05-07 DOI:10.1123/japa.2024-0252

Younguk Kim, Jin Hyun Kim, Angela L Ridgel

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引用次数: 0

Abstract

Background: Parkinson's disease (PD) affects motor and nonmotor functions, impacting PD-related quality of life. The role of physical activity (PA) in the management of PD symptoms is increasingly recognized.

Purpose: To examine the effects of PA levels on PD motor and nonmotor symptoms, and health-related quality of life, using the Fox Insight study's data set. It also examines PA's moderating effects on the age-PD motor function relationship.

Methods: In this cross-sectional observational study, 1,288 participants with PD (55.8% men, age: 64.54 ± 9.99) from the Fox Insight study were divided into four groups (N = 322 each) based on their PA level as measured by the Physical Activity Scale for the Elderly (PASE). PD motor and nonmotor symptoms were assessed using the Unified Parkinson's Disease Rating Scale-2 (UPDRS-2), Parkinson's Disease Questionnaire-8 (PDQ-8), Geriatric Depression Scale-Short Form, Penn Parkinson's Daily Activities Questionnaire-15, and EuroQol-Visual Analog Scale. Statistical analyses included Kruskal-Wallis, Pearson's correlation, and multiple linear regression, with alpha set at .05.

Results: Higher PASE correlated with better UPDRS-2, Parkinson's Disease Questionnaire-8, Geriatric Depression Scale-Short Form, Penn Parkinson's Daily Activities Questionnaire-15, and EuroQol-Visual Analog Scale. The study found significant influences of PASE on UPDRS-2, age, Geriatric Depression Scale-Short Form, body mass index, and EQ-VAS (R2adj = .174, F = 53.998, p < .001). Notably, PASE moderated the relationship between age and UPDRS-2, suggesting a pivoting role in slowing PD-related symptom progression with age (R2adj = .145, F = 73.47, p < .001).

Conclusion: Increased PA levels are associated with better outcomes in PD motor and nonmotor symptoms, improved PD-related quality of life, and a slowed progression of PD symptoms.

Implications: Promoting higher levels of PA in older adults with PD effectively manages motor and nonmotor symptoms of PD. In addition, early and consistent PA is the key to moderating the progression of PD symptoms.

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运动水平对老年帕金森病患者运动和非运动症状及生活质量的影响

背景：帕金森病（PD）影响运动和非运动功能，影响PD相关的生活质量。体育活动（PA）在PD症状管理中的作用越来越被认识到。目的：使用Fox Insight研究的数据集，研究PA水平对PD运动和非运动症状以及与健康相关的生活质量的影响。它还检查了PA对年龄- pd运动功能关系的调节作用。方法：在这项横断面观察性研究中，来自Fox Insight研究的1288名PD患者（55.8%为男性，年龄：64.54±9.99）根据老年人体力活动量表（PASE）测量的PA水平分为四组（N = 322）。PD运动和非运动症状采用统一帕金森病评定量表-2 （UPDRS-2）、帕金森病问卷-8 （PDQ-8）、老年抑郁量表-短表、佩恩帕金森日常活动问卷-15和euroqol -视觉模拟量表进行评估。统计分析采用Kruskal-Wallis、Pearson相关和多元线性回归，α集为0.05。结果：PASE越高，UPDRS-2、帕金森病问卷-8、老年抑郁量表-短表、Penn帕金森日常活动问卷-15和euroqol -视觉模拟量表越好。研究发现PASE对UPDRS-2、年龄、老年抑郁量表-短表、体重指数、EQ-VAS有显著影响（R2adj = 0.174, F = 53.998, p < 0.001）。值得注意的是，PASE调节了年龄与UPDRS-2之间的关系，表明PASE在减缓pd相关症状随年龄的进展中起着关键作用（R2adj = 0.145, F = 73.47, p < 0.001）。结论：PA水平的升高与PD运动和非运动症状的改善、PD相关生活质量的改善以及PD症状进展的减慢有关。意义：在老年PD患者中提高PA水平可以有效地控制PD的运动和非运动症状。此外，早期和持续的PA是减缓PD症状进展的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Aging and Physical Activity 医学-老年医学

CiteScore

2.60

自引率

6.70%

发文量

105

审稿时长

>12 weeks

期刊介绍： The Journal of Aging and Physical Activity (JAPA) is a multidisciplinary journal that publishes peer-reviewed original research reports, scholarly reviews, and professional-application articles on the relationship between physical activity and the aging process. The journal encourages the submission of articles that can contribute to an understanding of (a) the impact of physical activity on physiological, psychological, and social aspects of older adults and (b) the effect of advancing age or the aging process on physical activity among older adults. In addition to publishing research reports and reviews, JAPA publishes articles that examine the development, implementation, and evaluation of physical activity programs among older adults. Articles from the biological, behavioral, and social sciences, as well as from fields such as medicine, clinical psychology, physical and recreational therapy, health, physical education, and recreation, are appropriate for the journal. Studies using animal models do not fit within our mission statement and should be submitted elsewhere.