Old cytokine, new tricks: A refined model of interferon's antiviral activity.

IF 9.8 1区生物学 Q1 Agricultural and Biological Sciences

PLoS Biology Pub Date : 2025-05-07 eCollection Date: 2025-05-01 DOI:10.1371/journal.pbio.3003154

John W Schoggins

引用次数: 0

Abstract

Interferon is a central component of the vertebrate antiviral immune response, thought to act through induction of hundreds of interferon-stimulated genes, with some redundancy. Recent findings suggest a more refined 'limited set' model, in which distinct viruses are targeted by small subsets of the induced gene repertoire.

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旧的细胞因子，新的技巧：干扰素抗病毒活性的精细模型。

干扰素是脊椎动物抗病毒免疫反应的核心组成部分，被认为是通过诱导数百个干扰素刺激的基因起作用，有一些冗余。最近的发现提出了一种更精确的“有限集”模型，其中不同的病毒被诱导基因库的小子集靶向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY

CiteScore

15.40

自引率

2.00%

发文量

359

审稿时长

3-8 weeks

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