Sedentary lifestyle and hallux valgus: Unraveling the causal pathways and the mediating role of calcium homeostasis through mendelian randomization

IF 1.3 4区医学 Q2 Medicine

Journal of Foot & Ankle Surgery Pub Date : 2025-09-01 DOI:10.1053/j.jfas.2025.04.003

Maolin Liu , Yan Liu , Miao Sun , Zhongyao Zeng , Yuanzhi Song , Erlong Jia , Shengde Wu

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引用次数: 0

Abstract

The causal relationships between hallux valgus (HV), sedentary behavior and calcium homeostasis remain unclear. This study aimed to explore these associations using Mendelian randomization (MR) analysis. Leisure screen time (LST) was used as an indicator of sedentary behavior, while seven traits and three diseases were selected to represent calcium homeostasis. Two-sample MR was performed to assess the causal effect of sedentary behavior and calcium homeostasis on HV. Two-step MR was conducted to quantify the mediating roles of calcium homeostasis-related traits in the association between sedentary behavior and HV. Our results showed that longer LST was strongly associated with higher risk of HV (odds ratio (OR) = 1.1902, 95 %CI = 1.0129–1.3986, p = 0.0343). By contrast, serum calcium (S-Ca) levels were negatively associated with HV risk (OR = 0.7530, 95 %CI = 0.5675–0.9992, p = 0.0494). Mediation analyses found that S-Ca played an important mediating role in the effect of LST on HV (proportion mediated = 10.4 %). Our results extend the understanding of the pathogenesis of HV, and highlight the importance of preoperative metabolic optimization and postoperative behavioral and calcium supplementation strategies to enhance surgical outcomes and mitigate recurrence.

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久坐不动的生活方式和拇外翻：通过孟德尔随机化揭示钙稳态的因果途径和中介作用。

拇外翻（HV）、久坐行为和钙稳态之间的因果关系尚不清楚。本研究旨在利用孟德尔随机化（MR）分析来探讨这些关联。以休闲屏幕时间（LST）作为久坐行为的指标，选择7个特征和3种疾病来代表钙稳态。采用双样本MR评估久坐行为和钙稳态对HV的因果影响。两步磁共振是为了量化钙稳态相关特征在久坐行为和HV之间的关联中的中介作用。我们的结果显示，较长的LST与较高的HV风险密切相关（优势比(OR) = 1.1902, 95% CI = 1.0129-1.3986, p = 0.0343）。相比之下，血清钙（S-Ca）水平与HV风险呈负相关（OR = 0.7530, 95% CI = 0.6575 -0.9992, p = 0.0494）。中介分析发现，S-Ca在LST对HV的影响中起着重要的中介作用（中介比例为10.4%）。我们的研究结果扩展了对HV发病机制的理解，并强调了术前代谢优化和术后行为和补钙策略对提高手术效果和减轻复发的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Foot & Ankle Surgery ORTHOPEDICS-SURGERY

CiteScore

2.30

自引率

7.70%

发文量

234

审稿时长

29.8 weeks

期刊介绍： The Journal of Foot & Ankle Surgery is the leading source for original, clinically-focused articles on the surgical and medical management of the foot and ankle. Each bi-monthly, peer-reviewed issue addresses relevant topics to the profession, such as: adult reconstruction of the forefoot; adult reconstruction of the hindfoot and ankle; diabetes; medicine/rheumatology; pediatrics; research; sports medicine; trauma; and tumors.