The effects of del Nido cardioplegia combined with dexmedetomidine on cardiac surgery with cardiopulmonary bypass.

Abstract

ObjectiveTo evaluate the effects of dexmedetomidine administration and the use of del Nido cardioplegia in reducing the incidence of atrial fibrillation (AF) and delirium during the perioperative period.Methods448 patients were randomized into two groups: the treatment group received dexmedetomidine combined with del Nido cardioplegia, and the control group received normal saline placebo combined with Buckberg traditional cardioplegia. Each group included 224 patients. The occurrence of AF and delirium within 5 days after surgery, as well as other intraoperative and postoperative indicators, were noted.ResultsThere were no significant differences in preoperative indicators between the two groups. The incidences of AF and delirium events were significantly higher in the control group than in the treatment group.ConclusionWe found that del Nido cardioplegia combined with dexmedetomidine was safe in cardiac surgery with CPB and effectively reduced the incidence of postoperative AF and delirium.