Genetic Variability in Cisplatin Metabolism in Kidney Injury in Patients With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiotherapy.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-05-08 DOI:10.1002/hed.28179

Ericka Francislaine Dias Costa, Ana Maria Castro Ferreira, Marilda Mazzali, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

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Abstract

Background: This study investigated the roles of single nucleotide variants (SNVs) in genes of CDDP metabolism and their association with kidney dysfunction in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: A total of 109 patients with locally advanced HNSCC, treated with CDDP, had renal function evaluated by serum creatinine level and CKD-EPI formula, and underwent genotyping by polymerase chain reaction.

Results: Patients with GSTT1 present and ERCC1 c.354CT or TT genotypes showed 4.94% and 8.94% renal function reduction, respectively. GSTT1 present with TP53 c.215G>C (17.67%), GSTP1 c.313A>G with ERCC1 c.354C>T (17.57%), GSTP1 c.313A>G with MLH1 c.93G>A (12.49%), GSTP1 c.313A>G with MSH3 c.3133A>G (12.19%), ERCC1 c.354C>T with MLH1 c.93G>A (18.85%) and ERCC1 c.354C>T with MSH3 c.3133A>G (13.38%) combined genotypes were also associated with substantial declines in renal function.

Conclusions: Our data suggest that isolated and combined SNVs in genes enrolled in CDDP metabolism can be used to select patients for treatments that spare the kidneys from adverse effects.

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接受明确放化疗的头颈部鳞状细胞癌患者肾损伤中顺铂代谢的遗传变异。

背景：本研究探讨了CDDP代谢基因中单核苷酸变异（SNVs）的作用及其与头颈部鳞状细胞癌（HNSCC）患者肾功能障碍的关系。方法：109例局部晚期HNSCC患者，经CDDP治疗，采用血清肌酐水平和CKD-EPI公式评估肾功能，并采用聚合酶链反应进行基因分型。结果：存在GSTT1和ERCC1 c.354CT或TT基因型的患者肾功能下降分别为4.94%和8.94%。GSTT1合并TP53 C . 215g >C (17.67%), GSTP1 C . 313a >G合并ERCC1 C . 354c >T (17.57%), GSTP1 C . 313a >G合并MLH1 C . 93g >A (12.49%), GSTP1 C . 313a >G合并MSH3 C . 3133a >G (12.19%), ERCC1 C . 354c >T合并MLH1 C . 93g >A (18.85%), ERCC1 C . 354c >T合并MSH3 C . 3133a >G（13.38%）联合基因型均与肾功能显著下降相关。结论：我们的数据表明，CDDP代谢基因中的分离和联合snv可用于选择患者进行治疗，使肾脏免受不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.