Triphasic Changes in Ischemic Stroke Incidence With Age in Non-Valvular Atrial Fibrillation Patients - Pooled Analysis of the Shinken Database, J-RHYTHM Registry, and Fushimi AF Registry.
{"title":"Triphasic Changes in Ischemic Stroke Incidence With Age in Non-Valvular Atrial Fibrillation Patients - Pooled Analysis of the Shinken Database, J-RHYTHM Registry, and Fushimi AF Registry.","authors":"Shinya Suzuki, Takeshi Yamashita, Ken Okumura, Hirotsugu Atarashi, Masaharu Akao, Hiroshi Inoue","doi":"10.1253/circrep.CR-25-0009","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The basis for the specific age threshold for increasing of ischemic stroke in non-valvular atrial fibrillation (NVAF) patients has not been fully evaluated.</p><p><strong>Methods and results: </strong>We conducted a pooled analysis of 3,588 Japanese NVAF patients without anticoagulation therapy from the Shinken Database (n=1,099), the J-RHYTHM Registry (n=1,002), and the Fushimi AF Registry (n=1,487) to determine the incidence of ischemic stroke by age group; patients aged between 31 and 90 years (n=3,455) were analyzed. During a follow-up period of 1.47 years, 69 ischemic strokes occurred (1.33% per year). The incidence of ischemic stroke exhibited triphasic changes as follows: first, it ranged from 0.00% per year to 0.41% per year across the age groups between 31-35 and 46-50 years. Second, it then rose to 1.58% per year in the 56-60-years age group, remaining around 1% per year across the age groups between 56-60 and 71-75 years, with rates ranging from 0.83% to 1.58% per year. Last, it further increased to 2.35% per year in the 76-80-year age group, remaining around 2.5% per year across the age groups between 76-80 and 86-90 years.</p><p><strong>Conclusions: </strong>The incidence of ischemic stroke in NVAF patients exhibits triphasic changes with age, with notable increases observed in patients aged in their late 50s and late 70s.</p>","PeriodicalId":94305,"journal":{"name":"Circulation reports","volume":"7 4","pages":"303-307"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981666/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Circulation reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1253/circrep.CR-25-0009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/10 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The basis for the specific age threshold for increasing of ischemic stroke in non-valvular atrial fibrillation (NVAF) patients has not been fully evaluated.
Methods and results: We conducted a pooled analysis of 3,588 Japanese NVAF patients without anticoagulation therapy from the Shinken Database (n=1,099), the J-RHYTHM Registry (n=1,002), and the Fushimi AF Registry (n=1,487) to determine the incidence of ischemic stroke by age group; patients aged between 31 and 90 years (n=3,455) were analyzed. During a follow-up period of 1.47 years, 69 ischemic strokes occurred (1.33% per year). The incidence of ischemic stroke exhibited triphasic changes as follows: first, it ranged from 0.00% per year to 0.41% per year across the age groups between 31-35 and 46-50 years. Second, it then rose to 1.58% per year in the 56-60-years age group, remaining around 1% per year across the age groups between 56-60 and 71-75 years, with rates ranging from 0.83% to 1.58% per year. Last, it further increased to 2.35% per year in the 76-80-year age group, remaining around 2.5% per year across the age groups between 76-80 and 86-90 years.
Conclusions: The incidence of ischemic stroke in NVAF patients exhibits triphasic changes with age, with notable increases observed in patients aged in their late 50s and late 70s.