Relationship between inflammatory factors, lactic acid levels, acute skin failure, bad mood, and sleep quality.

IF 3.9 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2025-04-19 DOI:10.5498/wjp.v15.i4.102763

Yu-Fei Liu, Wen Cong, Chang-Ming Zhou, Yang Yu, Xin-Jie Zhang

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引用次数: 0

Abstract

Background: The central link between septic shock and acute skin failure (ASF) is the inflammatory response, which occurs throughout disease progression and can lead to systemic inflammatory response syndrome. Patients often experience bad moods, sleep disorders, and other health issues. Despite recognizing these factors, no studies have examined the correlation between inflammatory factors, lactic acid levels, ASF, mood disturbances, and sleep quality in critically ill patients. We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality, which may inform clinical treatment for septic shock and ASF.

Aim: To explore the relationship between inflammatory factors, lactic acid levels, the severity of ASF, bad mood, and sleep quality.

Methods: The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University, categorized into ASF (n = 35) or non-ASF groups (n = 115). We compared the peripheral blood inflammatory factors, including tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), lactic acid levels, skin mottling score (SMS), modified early warning score (MEWS), self-rating depression scale (SDS), self-rating anxiety scale (SAS), and Pittsburgh sleep quality index (PSQI) scores. Pearson correlation analysis assessed relationships among these variables.

Results: The ASF group had significantly higher levels of CRP (19.60 ± 4.10 vs 15.30 ± 2.96 mg/mL), IL-6 (298.65 ± 48.65 vs 268.66 ± 33.66 pg/L), procalcitonin, lactic acid (8.42 ± 2.32 vs 5.70 ± 1.27 mmol/L), SMS [0 (0, 1) vs 3 (2, 3)], MEWS (9.34 ± 1.92 vs 6.48 ± 1.96), SAS (61.63 ± 12.03 vs 53.71 ± 12.48), SDS (60.17 ± 12.64 vs 52.27 ± 12.64), and PSQI scores (14.23 ± 3.94 vs 8.69 ± 2.46) compared with the non-ASF group (all P < 0.001). Pearson correlation analysis revealed that IL-6, CRP, TNF-α, and lactic acid were positively correlated with SMS, MEWS, SAS, SDS, and PSQI scores (P < 0.05).

Conclusion: Peripheral blood levels of IL-6, CRP, TNF-α, and lactic acid correlate positively with SMS, MEWS, SAS, SDS, and PSQI in critically ill patients with ASF.

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炎症因子、乳酸水平、急性皮肤衰竭、不良情绪和睡眠质量的关系。

背景：感染性休克和急性皮肤衰竭（ASF）之间的中心联系是炎症反应，炎症反应发生在整个疾病进展过程中，并可导致全身炎症反应综合征。患者通常会经历心情不好、睡眠障碍和其他健康问题。尽管认识到这些因素，但没有研究检查危重患者炎症因子、乳酸水平、ASF、情绪障碍和睡眠质量之间的相关性。我们假设较高水平的炎症因子和乳酸与更严重的ASF、更差的情绪和睡眠质量有关，这可能为脓毒性休克和ASF的临床治疗提供信息。目的：探讨炎症因子、乳酸水平、ASF严重程度、不良情绪与睡眠质量的关系。方法：回顾性研究大连医科大学第二医院感染性休克患者150例，分为ASF组（n = 35）和非ASF组（n = 115）。我们比较了外周血炎症因子，包括肿瘤坏死因子-α (TNF-α)、c反应蛋白（CRP）、白细胞介素-6 （IL-6）、乳酸水平、皮肤斑点评分（SMS）、修正预警评分（MEWS）、抑郁自评量表（SDS）、焦虑自评量表（SAS）和匹兹堡睡眠质量指数（PSQI）评分。Pearson相关分析评估了这些变量之间的关系。结果:ASF组CRP的水平明显高于有(19.60±4.10 vs 15.30±2.96毫克/毫升),il - 6(298.65±48.65 vs 268.66±33.66 pg / L),原降钙素、乳酸(8.42±2.32 vs 5.70±1.27更易/ L),短信[0(0,1)和3(2、3)],马厩(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),和PSQI得分(14.23±3.94 vs 8.69±2.46)相比non-ASF组(P < 0.001)。Pearson相关分析显示，IL-6、CRP、TNF-α、乳酸与SMS、MEWS、SAS、SDS、PSQI评分呈正相关（P < 0.05）。结论：ASF危重患者外周血IL-6、CRP、TNF-α、乳酸水平与SMS、MEWS、SAS、SDS、PSQI呈正相关。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.