[Interactions between common drug metabolism and precautions for drug usage in Gilbert syndrome].

Q3 Medicine
D C Dacheng, C Liang, S J Zheng
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引用次数: 0

Abstract

Gilbert's syndrome is a type of hereditary disease caused by mutations in the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene, which leads to decreased UGT1A1 activity. Clinically, it is mainly characterized by increased unconjugated bilirubin and is often considered a benign disease. The incidence rate of Gilbert's syndrome is as high as 5%-10% in the population, and its interaction with commonly used clinical drugs deserves attention. On the one hand, some drugs can enhance or reduce UGT1A1 activity, causing bilirubin levels to decrease or increase. On the other hand, the decrease of UGT1A1 activity can also change part of drug metabolism, increase or reduce drug efficacy, and may cause adverse reactions and even endanger the patient's life in severe conditions. This article summarizes the interactions between common drug metabolism and precautions for drug usage in Gilbert syndrome.

【常见药物代谢与吉尔伯特综合征用药注意事项的相互作用】。
吉尔伯特综合征是一种由尿苷二磷酸葡萄糖醛酸糖基转移酶1A1 (UGT1A1)基因突变引起的遗传性疾病,导致UGT1A1活性降低。临床上主要表现为非共轭胆红素增高,常被认为是一种良性疾病。吉尔伯特综合征在人群中的发病率高达5%-10%,其与临床常用药物的相互作用值得关注。一方面,某些药物可以增强或降低UGT1A1活性,导致胆红素水平降低或升高。另一方面,UGT1A1活性的降低还可改变部分药物代谢,提高或降低药物疗效,严重时可引起不良反应,甚至危及患者生命。本文综述了吉尔伯特综合征常用药物代谢与用药注意事项之间的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
期刊介绍:
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