Artificial Intelligence Measured Tumor Burden and Pre-Treatment Circulating Tumor DNA in Human Papilloma Virus-Associated Oropharynx Cancer.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-05-05 DOI:10.1002/hed.28180

Mina Bakhtiar, Zezhong Ye, Jonathan D Schoenfeld, Homan Mohammadi, Jeffrey P Guenette, Eleni M Rettig, Glenn J Hanna, Benjamin H Kann

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引用次数: 0

Abstract

Background: Artificial intelligence (AI)-based imaging analysis and circulating tumor-associated DNA (ctDNA) are both being used diagnostically in HPV-driven oropharynx squamous cell carcinoma (HPV-OPSCC). We evaluated associations between AI-measured tumor burden and ctDNA.

Methods: We analyzed 170 patients treated definitively for HPV-OPSCC. All had pre-treatment serum tumor-tissue modified viral (TTMV) ctDNA levels. An AI algorithm measured tumor and lymph nodes on CT scans. Linear regressions detected associations between ctDNA (fragments/mL) and automated volumes, clinical tumor (T) and nodal (N) stage, and disease factors.

Results: Automated tumor volume (coeff = 39.43, p < 0.001), nodal volume (coeff = 39.54, p < 0.001), T stage (coeff = 1031.09, p = 0.009), and N stage (coeff = 1840, p = 0.018) were associated with ctDNA. On multivariable analysis, tumor (coeff = 34.79, p = 0.001) and nodal volumes (coeff = 24.68, p = 0.022) were associated with ctDNA; T and N stage were not.

Conclusions: Automated volumetrics are independently and more strongly associated with ctDNA, compared with clinical stage. Automated volumetrics provide a practical correlate to ctDNA.

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人工智能测量人乳头瘤病毒相关口咽癌肿瘤负荷和治疗前循环肿瘤DNA。

背景：基于人工智能（AI）的成像分析和循环肿瘤相关DNA （ctDNA）都被用于hpv驱动的口咽鳞状细胞癌（HPV-OPSCC）的诊断。我们评估了人工智能测量的肿瘤负荷与ctDNA之间的关系。方法：我们分析了170例明确治疗的HPV-OPSCC患者。所有患者治疗前血清肿瘤组织修饰病毒（TTMV） ctDNA水平。人工智能算法在CT扫描上测量肿瘤和淋巴结。线性回归检测到ctDNA（片段/mL）与自动体积、临床肿瘤(T)和淋巴结(N)分期以及疾病因素之间的关联。结果：自动肿瘤体积（coeff = 39.43, p）结论：与临床分期相比，自动肿瘤体积与ctDNA具有独立且更强的相关性。自动容积法提供了与ctDNA的实际关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.