The relationship of ¹⁸F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits.

IF 2.8 Q2 NEUROSCIENCES

Journal of Alzheimer's disease reports Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI:10.1177/25424823251314392

Katharina Woyk, Niels Hansen, Jens Wiltfang, Claudia Lange, Caroline Bouter

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Abstract

Background: Early biomarker-based diagnosis of Alzheimer's disease (AD) is essential, particularly with the increasing availability of new therapeutic options. However, the relationship between imaging and cerebrospinal fluid (CSF) biomarkers, especially in the context of ¹⁸Fluorine-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG-PET), remains insufficiently understood.

Objective: The aim of this study was the evaluation of the relationship between ¹⁸F-FDG-PET and other common fluid and imaging AD-biomarkers in a clinical cohort of patients with cognitive decline and suspected AD.

Methods: We included n = 90 patients with cognitive decline and clinically suspected AD that underwent ¹⁸F-FDG-PET imagining at our facility. Clinical and imaging data including patient characteristics, CSF biomarkers, Mini-Mental State Examination (MMSE), ¹⁸F-FDG-PET and ¹⁸F-Florbetaben-PET were retrospectively analyzed. PET images were quantified in several brain regions.

Results: ¹⁸F-FDG uptake correlated with CSF amyloid-β (Aβ)₄₀, Aβ₄₂, and the Aβ_42/40 ratio in several brain regions, but not with regional ¹⁸F-Florbetaben uptake. ¹⁸F-FDG uptake inversely correlated with t-tau and p-tau in CSF. Furthermore, a correlation between MMSE and ¹⁸F-FDG uptake was also detected in several brain regions. ¹⁸F-FDG-PET and its combination with CSF markers showed the highest predictive power for disease severity.

Conclusions: The study highlights the potential of integrating ¹⁸F-FDG-PET with CSF biomarkers to improve the diagnosis, prognosis, and monitoring of AD, emphasizing the complexity and regional specificity of biomarker interactions in neurodegeneration.

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18F-FDG-PET与记忆缺陷临床队列中痴呆的其他常见生物标志物的关系

背景：早期基于生物标志物的阿尔茨海默病（AD）诊断是必不可少的，特别是随着新的治疗选择的增加。然而，成像与脑脊液（CSF）生物标志物之间的关系，特别是在18氟-氟脱氧葡萄糖正电子发射断层扫描（18F-FDG-PET）的背景下，仍然没有得到充分的了解。目的：本研究的目的是评估18F-FDG-PET与认知能力下降和疑似AD患者临床队列中其他常见的液体和成像AD生物标志物之间的关系。方法：我们纳入了90例认知能力下降和临床疑似AD的患者，他们在我们的医院接受了18F-FDG-PET成像。回顾性分析临床和影像学资料，包括患者特征、脑脊液生物标志物、迷你精神状态检查（MMSE）、18F-FDG-PET和18F-Florbetaben-PET。PET图像在几个脑区被量化。结果：18F-FDG摄取与脑脊液淀粉样蛋白-β (Aβ)40、Aβ42和Aβ42/40比值相关，但与局部18F-Florbetaben摄取无关。18F-FDG摄取与脑脊液中t-tau和p-tau呈负相关。此外，在大脑的几个区域也检测到MMSE和18F-FDG摄取之间的相关性。18F-FDG-PET及其联合CSF标记物对疾病严重程度的预测能力最高。结论：该研究强调了18F-FDG-PET与CSF生物标志物结合的潜力，以改善AD的诊断、预后和监测，强调了神经退行性疾病中生物标志物相互作用的复杂性和区域特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's disease reports

CiteScore

2.80

自引率

0.00%

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