Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder (Paralichthys olivaceus).

IF 3.6 Q2 TOXICOLOGY
Frontiers in toxicology Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI:10.3389/ftox.2025.1560192
Bingbu Li, Guixing Wang, Xinyu Zheng, Mingyang Liu, Yucong Yang, Yuqin Ren, Yitong Zhang, Yufeng Liu, Zhongwei He, Jiangong Ren, Hailong Wan, Wei Cao, Yufen Wang, Xiaoyan Zhang, Jilun Hou
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Abstract

Introduction: Deltamethrin is a pyrethroid insecticide commonly used to kill animal parasites in aquaculture. However, increasing evidence suggests that deltamethrin affects the health of aquatic animals by causing tissue damage and even death.

Methods: In this study, the damage caused by deltamethrin to the gill and liver tissues, as well as its effects on oxidative stress and immune metabolism, were studied in Paralichthys olivaceus.

Results: We observed a positive correlation between the residual levels of deltamethrin (Del) and the exposure concentrations, with the highest residue detected in the 0.28 μg/L concentration group (0.0684 mg/kg at 7 days). Then, we observed different degrees of damage to the gill and liver tissues of the Paralichthys olivaceus, including swelling, apical fusion, shedding of gill secondary lamellae, liver cell necrosis, and nuclear vacuolization, by observing tissue sections. Lysozyme enzyme activity increased, whereas catalase and alkaline phosphatase enzyme activities decreased. The liver transcriptome results of the control and high-concentration (0.28 μg/L) groups showed that there were 697 differentially expressed genes, including 390 upregulated and 307 downregulated genes. These differentially expressed genes were significantly enriched in oxidation-reduction, ferroptosis, steroid biosynthesis, and apoptosis pathways.

Discussion: In summary, we found that deltamethrin induces oxidative stress and metabolic disorders in P. olivaceus and leads to inflammation. However, the fish body resists such damage through a complex regulatory network. These experimental results provide a theoretical reference for the safe use of deltamethrin in P. olivaceus.

溴氰菊酯会导致牙鲆(牙鲆)鳃肝损伤、氧化应激、炎症和代谢紊乱。
简介:溴氰菊酯是一种拟除虫菊酯类杀虫剂,在水产养殖中常用来杀灭动物寄生虫。然而,越来越多的证据表明,溴氰菊酯通过造成组织损伤甚至死亡来影响水生动物的健康。方法:研究溴氰菊酯对橄榄比目鱼鳃和肝脏组织的损伤,以及对氧化应激和免疫代谢的影响。结果:溴氰菊酯残留量与暴露浓度呈正相关,浓度为0.28 μg/L组残留量最高(7 d时为0.0684 mg/kg)。然后,我们通过组织切片观察到橄榄鲆鳃和肝脏组织不同程度的损伤,包括肿胀、根尖融合、鳃次级片脱落、肝细胞坏死和核空泡化。溶菌酶活性升高,过氧化氢酶和碱性磷酸酶活性降低。对照和高浓度(0.28 μg/L)组的肝脏转录组结果显示,差异表达基因697个,其中上调基因390个,下调基因307个。这些差异表达的基因在氧化还原、铁下垂、类固醇生物合成和细胞凋亡途径中显著富集。讨论:综上所述,我们发现溴氰菊酯可诱导橄榄虾氧化应激和代谢紊乱,并导致炎症。然而,鱼的身体通过一个复杂的调节网络来抵抗这种伤害。这些实验结果为溴氰菊酯在石斑鱼中的安全使用提供了理论参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
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审稿时长
13 weeks
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