Current and future perspectives for structural biology at the Grenoble EPN campus: a comprehensive overview.

IF 2.5 3区物理与天体物理

Journal of Synchrotron Radiation Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI:10.1107/S1600577525002012

Andrew A McCarthy, Shibom Basu, Florent Bernaudat, Matthew P Blakeley, Matthew W Bowler, Philippe Carpentier, Gregory Effantin, Sylvain Engilberge, David Flot, Frank Gabel, Lukas Gajdos, Jos J A G Kamps, Eaazhisai Kandiah, Romain Linares, Anne Martel, Igor Melnikov, Estelle Mossou, Christoph Mueller-Dieckmann, Max Nanao, Didier Nurizzo, Petra Pernot, Alexander Popov, Antoine Royant, Daniele de Sanctis, Guy Schoehn, Romain Talon, Mark D Tully, Montserrat Soler-Lopez

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引用次数: 0

Abstract

The European Photon and Neutron campus in Grenoble is a unique site, encompassing the European Synchrotron Radiation Facility Extremely Brilliant Source, the Institut Laue-Langevin, the European Molecular Biology Laboratory and the Institut de Biologie Structurale. Here, we present an overview of the structural biology beamlines, instruments and support facilities available on the EPN campus. These include advanced macromolecular crystallography using neutrons or X-rays, small-angle X-ray or neutron scattering, cryogenic electron microscopy, and spectroscopy. These highly complementary experimental approaches support cutting-edge research for integrated structural biology in our large user community. This article emphasizes our significant contributions to the field, outlines current advancements made and provides insights into our future prospects, offering readers a comprehensive understanding of the EPN campus's role in advancing integrated structural biology research.

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格勒诺布尔EPN校园结构生物学的当前和未来展望：全面概述。

位于格勒诺布尔的欧洲光子和中子校园是一个独特的场所，包括欧洲同步加速器辐射设施极亮源，劳厄朗格万研究所，欧洲分子生物学实验室和结构生物研究所。在这里，我们提出了结构生物学光束线，仪器和支持设施的概述，可在EPN校园。这些包括使用中子或x射线的高级大分子晶体学，小角度x射线或中子散射，低温电子显微镜和光谱学。这些高度互补的实验方法在我们的大型用户群体中支持集成结构生物学的前沿研究。这篇文章强调了我们在该领域的重大贡献，概述了当前取得的进展，并提供了对我们未来前景的见解，让读者全面了解EPN校园在推进综合结构生物学研究中的作用。

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来源期刊

Journal of Synchrotron Radiation INSTRUMENTS & INSTRUMENTATIONOPTICS&-OPTICS

CiteScore

5.60

自引率

12.00%

发文量

289

审稿时长

1 months

期刊介绍： Synchrotron radiation research is rapidly expanding with many new sources of radiation being created globally. Synchrotron radiation plays a leading role in pure science and in emerging technologies. The Journal of Synchrotron Radiation provides comprehensive coverage of the entire field of synchrotron radiation and free-electron laser research including instrumentation, theory, computing and scientific applications in areas such as biology, nanoscience and materials science. Rapid publication ensures an up-to-date information resource for scientists and engineers in the field.