[Significance of HALP Score as a Prognostic Indicator for Newly Diagnosed Multiple Myeloma].

Q4 Medicine

中国实验血液学杂志 Pub Date : 2025-04-01 DOI:10.19746/j.cnki.issn.1009-2137.2025.02.019

Kuan-Shun Zhang, Dian-Liang Lyu, Lin Shi

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引用次数: 0

Abstract

Objective: To investigate the significance of HALP score as a prognostic indicator for newly diagnosed multiple myeloma (MM).

Methods: Clinical data of 62 newly diagnosed MM patients in our hospital from January 2020 to December 2022 were collected and retrospectively analyzed. The difference in age, sex, DS stage, R-ISS stage, M protein type, serum creatinine (Scr), β₂-microglobulin (β₂-MG), blood calcium, lactate dehydrogenase (LDH), hemoglobin (Hb), albumin (ALB), platelet count (PLT), and absolute lymphocyte count (ALC) between patients with low and high HALP scores were analyzed. The prognostic value of the above indexes in newly diagnosed MM patients was analyzed by univariate and multivariate analysis.

Results: The optimal cut-off value of HALP score was 41 determined by X-tile software. Based on this, 62 patients were divided into a high HALP group (HALP>41, n=25) and a low HALP group (HALP≤41, n=37). The proportion of patients with Hb≥100 g/L in the high HALP group was significantly higher than that in the low HALP group (P <0.05). The median overall survival (OS) time of patients in the high HALP group and low HALP group were 29 (9-39) months and 20 (4-29) months, respectively, with statistically significant difference between the two groups (P <0.01). Univariate analysis showed that R-ISS stage, ALB, Hb, ALC and HALP were closely related to the prognosis of patients (P <0.05). COX regression multivariate analysis showed that R-ISS stage Ⅲ (HR=4.443, 95%CI : 1.480-13.343，P =0.008) and HALP≤41(HR=8.823, 95%CI : 1.858-41.910，P =0.006) were independent risk factors for shortened OS in newly diagnosed MM patients. The median OS of patients with high HALP at R-ISS stage Ⅲ was significantly higher than that of patients with low HALP at the same stage, and the difference was statistically significant (P <0.05).

Conclusion: HALP score can be used as a prognostic indicator for newly diagnosed MM patients.

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【HALP评分作为新诊断多发性骨髓瘤预后指标的意义】。

目的：探讨HALP评分作为新诊断多发性骨髓瘤（MM）预后指标的意义。方法：收集我院2020年1月至2022年12月62例新诊断MM患者的临床资料进行回顾性分析。分析低、高HALP评分患者在年龄、性别、DS分期、R-ISS分期、M蛋白类型、血清肌酐（Scr）、β2-微球蛋白（β2-MG）、血钙、乳酸脱氢酶（LDH）、血红蛋白（Hb）、白蛋白（ALB）、血小板计数（PLT）、绝对淋巴细胞计数（ALC）等方面的差异。通过单因素和多因素分析分析上述指标对新诊断MM患者的预后价值。结果：采用X-tile软件确定HALP评分的最佳临界值为41。在此基础上，将62例患者分为高HALP组（HALP≤41,n=25）和低HALP组（HALP≤41,n=37）。高HALP组Hb≥100 g/L患者比例显著高于低HALP组（P P P HR=4.443, 95%CI: 1.480 ~ 13.343,P =0.008）和HALP≤41（HR=8.823, 95%CI: 1.858 ~ 41.910,P =0.006）是新诊断MM患者OS缩短的独立危险因素。R-ISS期高HALP患者Ⅲ的中位OS显著高于同期低HALP患者，差异有统计学意义(P)结论：HALP评分可作为新诊断MM患者的预后指标。

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