Prognostic Models for Overall and Disease-Specific Survival in Palate Squamous Cell Carcinoma: Implications for Postoperative Radiotherapy.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-04-24 DOI:10.1002/hed.28172

Di Zhang, Lixi Li

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Abstract

Background: This study aimed to develop lymph node ratio (LNR)-integrated nomograms to predict overall survival (OS) and disease-specific survival (DSS) in palate squamous cell carcinoma (PSCC) and to guide postoperative radiotherapy (PORT) decisions.

Methods: Data from PSCC patients were analyzed to identify prognostic factors, and nomograms were constructed. Performance was assessed using the area under the curve (AUC), calibration plots, and decision curve analysis. PORT benefits were evaluated across risk groups.

Results: Among 959 patients, 5-year OS and DSS were 47.0% and 60.9%, respectively. LNR > 6% was associated with significantly increased mortality. The nomograms showed favorable accuracy (OS 1/3/5-year AUC: 0.780/0.703/0.745; DSS 1/3/5-year AUC: 0.789/0.714/0.700), with calibration plots showing excellent agreement between predicted and observed survival. High-risk patients had significantly poorer survival outcomes than low-risk patients, with PORT benefiting only high-risk groups.

Conclusion: The LNR-based nomograms improve prognostic prediction and optimize PORT selection, offering valuable guidance for personalized treatment.

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腭鳞状细胞癌总体和疾病特异性生存的预后模型：对术后放疗的影响。

背景：本研究旨在建立淋巴结比（LNR）综合nomogram预测腭鳞状细胞癌（PSCC）患者的总生存期（OS）和疾病特异性生存期（DSS），并指导术后放疗（PORT）决策。方法：对PSCC患者的资料进行分析，确定预后因素，并构建线图。使用曲线下面积（AUC）、校准图和决策曲线分析来评估性能。对不同风险组的PORT获益进行评估。结果：959例患者5年OS和DSS分别为47.0%和60.9%。LNR低于6%与死亡率显著增加相关。图显示了良好的准确度(OS 1/3/5- 5 AUC: 0.780/0.703/0.745；DSS 1/3/5- 5年AUC: 0.789/0.714/0.700)，校准图显示预测生存和观察生存之间非常一致。高危患者的生存结果明显低于低危患者，PORT仅对高危人群有利。结论：基于lnr的形态图改善了预后预测，优化了PORT的选择，为个性化治疗提供了有价值的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.