Surgical Repair of Deep Melting Ulcers With Freeze-Dried Amniotic Membrane Transplantation in Dogs and Cats.

IF 1.7 4区农林科学 Q2 VETERINARY SCIENCES

Veterinary ophthalmology Pub Date : 2025-05-05 DOI:10.1111/vop.70023

Cloé Lengellé

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引用次数: 0

Abstract

Purpose: To determine the efficacy of freeze-dried amniotic membrane (FDAM) used in veterinary medicine (Vetrix EyeQ) for the surgical treatment of deep melting ulcers in dogs and cats.

Materials and methods: A total of 15 dogs and 5 cats treated for deep melting corneal ulcers were included in this retrospective study. Following keratectomy, a simple or multilayer FDAM was placed into the keratectomy bed and sutured with 9/0 polyglactin suture material. A temporary third eyelid flap was performed for each case. Follow-up examinations were performed on average 18, 45, and 90 days after surgery. Final evaluation included assessment of corneal healing, preserved vision, and residual corneal opacities.

Results: A total of 20 eyes were treated between 2019 and 2023. Nine dog and four cat breeds were represented. Mean healing time was 17 ± 2 days. At 18 days postsurgery, inflammatory reaction with superficial vascularization was present in all eyes (20/20). At 45 days, 45% (9/20) of eyes showed persistent corneal neovascularization, mild corneal fibrosis, and focal corneal pigmentation. At 90 days, persistent severe pigmentation was observed in 10% (2/20) of eyes. Corneal transparency was successfully restored, and vision was preserved in 90% of cases (18/20).

Conclusion: FDAM transplantation was effective in treating melting corneal ulcers in dogs and cats.

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冻干羊膜移植修复犬、猫深融性溃疡。

目的：探讨兽药用冻干羊膜（Vetrix EyeQ）在犬猫深度融化性溃疡手术治疗中的疗效。材料和方法：回顾性研究15只狗和5只猫治疗深度融化性角膜溃疡。角膜切除术后，将单层或多层FDAM放置在角膜切除术床上，用9/0聚乳酸缝线材料缝合。每个病例均行临时第三眼睑皮瓣。术后平均随访18、45、90天。最后的评估包括角膜愈合、视力保留和残留的角膜混浊。结果：2019 - 2023年共治疗20只眼。代表了9种狗和4种猫。平均愈合时间17±2天。术后18天，所有眼睛均出现炎症反应并伴有浅表血管形成（20/20）。45 d时，45%（9/20）的眼睛出现持续的角膜新生血管，轻度角膜纤维化和角膜色素沉着。90 d时，10%（2/20）的眼睛出现持续严重的色素沉着。成功恢复角膜透明，90%（18/20）的患者视力得以保留。结论：FDAM移植治疗犬、猫角膜融化性溃疡是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary ophthalmology 农林科学-兽医学

CiteScore

2.70

自引率

37.50%

发文量

审稿时长

12-24 weeks

期刊介绍： Veterinary Ophthalmology is a peer-reviewed, international journal that welcomes submission of manuscripts directed towards academic researchers of veterinary ophthalmology, specialists and general practitioners with a strong ophthalmology interest. Articles include those relating to all aspects of: Clinical and investigational veterinary and comparative ophthalmology; Prospective and retrospective studies or reviews of naturally occurring ocular disease in veterinary species; Experimental models of both animal and human ocular disease in veterinary species; Anatomic studies of the animal eye; Physiological studies of the animal eye; Pharmacological studies of the animal eye.