Metagenomics for IgA-coated gut microbiota: from taxonomy to function.

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2025-04-16 DOI:10.1016/j.tim.2025.04.001

Shuqin Zeng, Shaopu Wang, Dezhi Mu

引用次数: 0

Abstract

Immunoglobulin A (IgA) establishes intricate interactions with human gut microbiota, thereby forming IgA-coated microbiota. This forum first explores state-of-the-art metagenomic techniques for characterizing IgA-coated microbiota. Thereafter, metagenomic insights into its taxonomic diversity and microbial genomic functions that mediate IgA coating are provided. Finally, clinical implications for human health are highlighted.

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iga包被肠道微生物群的宏基因组学：从分类到功能。

免疫球蛋白A （IgA）与人体肠道微生物群建立了复杂的相互作用，从而形成了IgA包被的微生物群。本次论坛首先探讨了用于表征iga包被微生物群的最先进的宏基因组技术。此后，宏基因组学的见解，其分类多样性和微生物基因组功能介导IgA包衣提供。最后，强调了对人类健康的临床影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.