Preoperative myosteatosis as a novel prognostic biomarker after anatomical lung resection for non-small cell lung cancer.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-06-01 Epub Date: 2025-04-26 DOI:10.1007/s00595-025-03049-3

Seijiro Sato, Saeko Nakayama, Hirohiko Shinohara

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引用次数: 0

Abstract

Purpose: Myosteatosis, or excessive deposition of adipose tissue within skeletal muscle, has been widely used to explain an impaired muscle quality. This study aimed to investigate the association between preoperative myosteatosis and surgical outcomes in patients with non-small-cell lung cancer (NSCLC).

Methods: We retrospectively examined 492 patients who underwent anatomical lung resection for stages I-III NSCLC between January 2014 and December 2022. The patients were divided into low- and high-paraspinal muscle density (MD) groups based on the lowest quartile cutoff value of MD on contrast-enhanced computed tomography, with the low-MD group defined as having myosteatosis.

Results: The five-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly lower in the myosteatosis group than in the control group (59.1% vs. 86.8%, P < 0.001; 52.0% vs. 72.6%, P < 0.001, respectively). A multivariate analysis identified myosteatosis as an independent predictor of OS (hazard ratio [HR], 2.809; 95% confidence interval [CI], 1.781-4.430; P < 0.001) and RFS (HR, 1.894; 95%CI, 1.340-2.678; P < 0.001). There was a significant correlation between myosteatosis and prolonged air leak postoperatively (P = 0.039).

Conclusion: Perioperative nutritional and exercise interventions facilitate changes in body composition, which may improve the outcomes in patients with lung cancer undergoing anatomical resection.

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非小细胞肺癌解剖肺切除术后术前肌骨增生作为一种新的预后生物标志物。

目的：骨骼肌骨化症，或骨骼肌内脂肪组织的过度沉积，已被广泛用于解释肌肉质量受损。本研究旨在探讨非小细胞肺癌（NSCLC）患者术前肌骨化病与手术结果之间的关系。方法：我们回顾性研究了2014年1月至2022年12月期间492例接受解剖性肺切除术的I-III期NSCLC患者。根据对比增强计算机断层扫描显示的椎旁肌密度（MD）的最低四分位数临界值，将患者分为低和高椎旁肌密度组，低MD组定义为患有肌骨化症。结果：肌骨化组5年总生存率（OS）和无复发生存率（RFS）明显低于对照组（59.1% vs. 86.8%）， P结论：围手术期营养和运动干预有助于改变机体成分，可能改善解剖切除肺癌患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.