AMPLIFY: A second-generation BTK inhibitor for fixed-duration therapy in chronic lymphocytic leukemia.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-04-11 DOI:10.1016/j.medj.2025.100665

Stefano Molica

引用次数: 0

Abstract

Recent advancements in chronic lymphocytic leukemia (CLL) treatment emphasize fixed-duration (FD) strategies, notably venetoclax with obinutuzumab or ibrutinib, now endorsed by ESMO guidelines. The AMPLIFY phase 3 trial highlights acalabrutinib-venetoclax combinations, demonstrating superior progression-free survival and manageable safety.¹ These findings support FD regimens as a paradigm shift, optimizing efficacy, safety, and patient convenience in frontline CLL therapy.

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AMPLIFY：第二代BTK抑制剂，用于慢性淋巴细胞白血病的固定疗程治疗。

慢性淋巴细胞白血病（CLL）治疗的最新进展强调了固定时间（FD）策略，特别是venetoclax联合obinutuzumab或ibrutinib，现已得到ESMO指南的认可。AMPLIFY 3期试验强调了acalabrutinib-venetoclax联合治疗，显示出优越的无进展生存期和可管理的安全性这些发现支持FD方案作为一种范式转变，优化了一线CLL治疗的疗效、安全性和患者便利性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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