[A preliminary study on the effects of vestibular migraine, Meniere's disease and comorbidities on emotional status and cognitive function].

Q4 Medicine
E Tian, J Q Guo, Z Q Guo, J Y Chen, Z H Zhou, S Y Shi, X X Yu, W D Xu, S Zhou, X B Gao, J Wang, S L Zhang
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引用次数: 0

Abstract

Objective: This study aims to investigate the differences in emotional status and cognitive function among patients with vestibular migraine (VM), Meniere's disease (MD), and their comorbidity (VMMD), and to analyze key factors influencing cognitive function. Methods: This cross-sectional study included 96 outpatients (32 males, 64 females, aged 21-73 years) from the Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, between December 2022 and December 2023. The study population consisted of 31 VM patients (VM group), 36 MD patients (MD group), and 29 VMMD patients (VMMD group), along with 32 healthy controls (16 males, 16 females, aged 19-74 years). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), while emotional status and somatization symptoms were evaluated through the Generalized Anxiety Disorder scale, Patient Health Questionnaire Depression scale, Symptom Checklist-90, and the Self-rating Somatization Symptom scale. Multiple linear regression analysis was conducted to explore the influence of different variables on cognitive function. Results: The total MoCA score in the VMMD group (26.0 [24.5, 28.0]) was significantly lower than that in the control group (28.0 [27.0, 29.0]) and the MD group (28.0 [26.0, 30.0]) (P=0.006). VMMD patients exhibited significant impairments in specific cognitive domains, including visuospatial/executive function, delayed recall, and orientation (P<0.05). Patients with VM, MD, and VMMD showed higher rates of anxiety, depression, and somatization symptoms compared to the control group (P<0.05), with the VMMD group experiencing the most severe emotional distress. Multiple linear regression analysis identified education level and vestibular disease type as key factors affecting cognitive function, with a university-level education predicting higher MoCA scores (P<0.001), while VMMD was associated with cognitive decline (P<0.01). Conclusions: Patients with VM and MD, particularly those with comorbid VMMD, exhibit significant emotional distress. Cognitive impairments are present in VM and VMMD patients, affecting different cognitive domains. These factors should be comprehensively considered in clinical assessments to develop more effective treatment strategies.

前庭偏头痛、梅尼埃病及其合并症对情绪状态和认知功能影响的初步研究
目的:探讨前庭偏头痛(VM)、梅尼埃病(MD)及其合并症(VMMD)患者情绪状态和认知功能的差异,并分析影响认知功能的关键因素。方法:选取华中科技大学同济医学院协和医院耳鼻咽喉科门诊患者96例(男32例,女64例,年龄21 ~ 73岁),于2022年12月至2023年12月进行横断面研究。研究人群包括31名VM患者(VM组),36名MD患者(MD组)和29名VMMD患者(VMMD组),以及32名健康对照组(16名男性,16名女性,年龄19-74岁)。采用蒙特利尔认知评估(MoCA)评估认知功能,采用广泛性焦虑障碍量表、患者健康问卷抑郁量表、症状表-90和躯体化症状自评量表评估情绪状态和躯体化症状。采用多元线性回归分析,探讨不同变量对认知功能的影响。结果:VMMD组MoCA总分(26.0[24.5,28.0])明显低于对照组(28.0[27.0,29.0])和MD组(28.0 [26.0,30.0])(P=0.006)。VMMD患者在特定认知领域表现出显著的损伤,包括视觉空间/执行功能、延迟回忆和定向(ppppp)。结论:VM和MD患者,特别是合并VMMD的患者,表现出显著的情绪困扰。VM和VMMD患者均存在认知障碍,影响不同的认知领域。在临床评估中应综合考虑这些因素,以制定更有效的治疗策略。
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
12432
期刊介绍: Chinese journal of otorhinolaryngology head and neck surgery is a high-level medical science and technology journal sponsored and published directly by the Chinese Medical Association, reflecting the significant research progress in the field of otorhinolaryngology head and neck surgery in China, and striving to promote the domestic and international academic exchanges for the purpose of running the journal. Over the years, the journal has been ranked first in the total citation frequency list of national scientific and technical journals published by the Documentation and Intelligence Center of the Chinese Academy of Sciences and the China Science Citation Database, and has always ranked first among the scientific and technical journals in the related fields. Chinese journal of otorhinolaryngology head and neck surgery has been included in the authoritative databases PubMed, Chinese core journals, CSCD.
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